TABLE 2.

Some labeling synthons prepared from aryliodonium ylides

Entry	Labeling Synthon	Precursor		Labeling Conditions				Yield,b %	References
		R1	Aux−a	Mode	Solvent	°C	min
1	[18F]3-Fluorobromobenzene	3-Br	C	Batch	DMF	130	10	72 ± 3	Yuan et al115
2	[18F]4-Fluoroiodobenzene	4-I	A	Batch	DMSO	110	15	70 ± 10	Kügler et al101
3	[18F]3-Fluorobenzaldehyde	3-CHO	B	Batch	DMF	120	10	7-52	Petersen et al116
4	[18F]3-Fluorobenzyl azide	3-CH2N3	B	Batch	DMF	120	ns	69 ± 8	Wang et al117
5	[18F]4-Fluorobenzyl azide	4-CH2N3	B	Batch	DMF	120	10	70 ± 4 (52 ± 2)
6	[18F]4-Fluorobenzyl azide	4-CH2N3	B	Batch	DMF	120	10	(25 ± 10) c	Rotstein et al67
7	[18F]4-Fluorobenzyl azide	4-CH2N3	B	MR	DMF	210	~1	68 ± 5 (24 ± 0)	Calderwood et al75
8	[18F]3-Fluorobenzoic acid methyl ester	3-CO2Me	B	Batch	DMF	120	10	77 ± 7	Rotstein et al67
9	[18F]2-(3-Fluorophenyl)ethylamined	3-(CH2)2NHBoc	A	Batch	DMF	110	10	~70	Drerup et al118
10	[18F]1-(2-Azidoethoxy)-4-bromo-2-fluorobenzene	2-(O(CH2)2N3)	B	Batch	DMF	120	10	69 ± 2	Wang et al117
11	[18F]1-((2-Azidoethoxy)methyl)-4-bromo-2-fluorobenzene	2-(CH2 O(CH2)2N3)	B	Batch	DMF	120	10	90 ± 2	Wang et al117

Abbreviations: DMF, dimethylformamide; DMSO, dimethyl sulfoxide; MR, microreactor (microfluidic); ns, not specified.

^a

^bValues in plain type are yields before isolation. Values in bold and parentheses are yields after isolation.

^cUncorrected for decay.

^dProcess is 2 steps. Data are for the radiofluorination step.