TABLE 5.

Radiotracers prepared from aryliodonium ylides

Entry	Radiotracer Target		Precursor (ArI+Aux−)		Labeling conditions				Yield,b %	Reference
	Name	Structure	ArI+	Aux−a	Mode	Solvent	°C	min
1	[18F]4-FPPMP			A	Batch (2 steps)	MeCN	130	20	20	Cardinale et al94
2	[18F]3-FPPMP			A	Batch (2 steps)	MeCN	120	20	(20 ± 5)	Cardinale et al94
3	[18F]FPEB			B	Batch (1 step)	DMF	80	5	49 ± 6	Stephenson et al139
4	[18F]FPEB			B	MR (1 step)	DMF	200	~1	(20 ± 5)	Stephenson et al139
5	[18F]LY2459989			B	MR (2 steps)	DMF	120	5	76	Cai et al140
6	[18F]LY2459989			B	Batch (2 steps)	DMF	80	5	49 (30-43)	Cai et al140
7	[18F]PFH			B	Batch (2 steps)	DMF	130	10	(46 ± 3)	Nkepang et al142
8	[18F]4-FPhe			B	Batch (2 steps)	DMF	120	10	55 ± 4	Rotstein et al67
9	[18F]CIMBI-198			B	Batch with TEMPO (2 step)	DMF	135	20	12 ± 3 (2)	Petersen et al143
10	18F-Labeled 5-HT2A receptor radiotracer			B	Batch (2 steps) with TEMPO	DMF	135	20	76-77 (10-12)	Petersen et al143
11	[18F]Lorlatinib analog			B	Batch (2 steps)	DMF	80	10	(14) c	Collier et al144
12	[18F]FDPA			C	Batch (1 step)	DMF	120	15	40 ± 3	Wang et al145
13	[18F]FDPA			C	Batch (1 step)	MeCN	120	12	45 ± 8	Wang et al145
14	[18F]Safinamide			C	Batch (2 steps)	DMF	120	10	15	Rotstein et al93
15	[18F]FMT			C	Batch (2 steps)	DMF	120	20	60 (12)cb	Rotstein et al93
16	[18F]MFBG			C	Batch (2 steps)	DMF	120	10	70 (14)c	Rotstein et al93

Abbreviations: DMF, dimethylformamide; [¹⁸F]FMT, [¹⁸F]l-2-fluoro-meta-tyrosine; MeCN, acetonitrile; [¹⁸F]MFBG, [¹⁸F]1-(3-Fluorobenzyl)guanidine; TEMPO, 2,2,6,6-tetramethyl-1-piperidinyloxyl.

^a

^bValues in bold and parentheses are yields after isolation.

^cNot decay corrected.