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[Preprint]. 2023 Mar 29:2023.03.28.534594. [Version 1] doi: 10.1101/2023.03.28.534594

Figure 3: Terpenes lack reward liability as measured by conditioned place preference.

Figure 3:

Male and female CD-1 mice had vehicle, morphine (10 mg/kg, SC), or terpene (200 mg/kg, IP) injected over a 4 day conditioning trial (see Methods), with preference measurement on day 5. Data shown represents the mean ± SEM of the % time spent in paired chamber over 3–5 technical replicates per group, with sample sizes noted in the legend. Values over 50% represent preference while values under 50% represent aversion. A) Summary data shown for each group. *, ** = p < 0.05, 0.01 vs. the baseline for each group by RM 2 Way ANOVA with Sidak’s post hoc test. Morphine shows a positive preference (reward), validating the assay. B) The baseline and post-conditioning trajectories for each mouse in each group are shown.