Skip to main content
[Preprint]. 2023 Mar 29:2023.03.28.534594. [Version 1] doi: 10.1101/2023.03.28.534594

Figure 8: Most terpenes evoke antinociception in CIPN via a spinal cord site of action.

Figure 8:

Male and female CD-1 mice had CIPN induced and measured as described in the Methods. Data shown is the mean ± SEM, performed in 2–4 technical replicates for each experiment, with sample sizes noted in each graph. BL = baseline. A) Vehicle or terpene (100 nmol, IT) injected into the spinal cord in CIPN mice and mechanical allodynia measured. *, **, **** = p < 0.05, 0.01, 0.0001 vs. same time point vehicle group by RM 2 Way ANOVA with Sidak’s post hoc test. B) AUC values calculated from the data in A (all vehicle groups combined). **, **** = p < 0.01, 0.0001 vs. vehicle group by 1 Way ANOVA with Fisher’s Least Significant Difference post hoc test. All terpenes except β-pinene induce antinociception when injected into the spinal cord.