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[Preprint]. 2023 Apr 1:2023.03.30.534923. [Version 1] doi: 10.1101/2023.03.30.534923

Figure 3. Examples of mushroom body abnormalities in SSRIDD and CdLS fly models.

Figure 3.

Images of a wild type mushroom body annotated with measurement descriptors for (A) mushroom body alpha and beta lobes, and heel-heel normalization measurement; and (B) ellipsoid body measurements. Images of select brains from flies with Ubi156-GAL4-mediated RNAi knockdown of osa showing (C) stunted alpha lobe outgrowth and narrowed alpha lobe head in a female osa-deficient fly brain; and (D) beta lobe crossing the midline/fused beta lobes, as well as a skinny alpha lobe in a male osa-deficient fly brain. Images shown are z-stack maximum projections from confocal imaging. Triangular arrowheads indicate the abnormalities. The scale bar represents 25 μM.