Table 1. Drosophila genes used in fly models.
The table indicates fly genes used in SSRIDD and CdLS fly models, as well as the respective human orthologs and MIM numbers, associated human disease and respective MIM numbers, and DIOPT scores. Human orthologs are only included in the table if the DIOPT score is greater than 9.
| Fly Gene | Human Ortholog(s) | Human Ortholog MIM number(s) | Associated Human Disease | Phenotype MIM Number(s) | DIOPT score |
|---|---|---|---|---|---|
| brm | SMARCA2, SMARCA4 | 600014, 603254 | SSRIDD (NCBRS, CSS 4) | 601358, 614609 | 13, 12 |
| oso | ARID1A, ARID1B | 603024, 614556 | SSRIDD (CSS 2, CSS 1) | 614607, 135900 | 12, 12 |
| SMC1 | SMC1A | 300040 | Cornelia de Lange syndrome 2 | 300590 | 12 |
| SMC3 | SMC3 | 606062 | Cornelia de Lange syndrome 3 | 610759 | 12 |
| Snr1 | SMARCB1 | 601607 | SSRIDD (CSS 3) | 614608 | 15 |
| vtd | RAD21, RAD21L1 | 606462, 619533 | Cornelia de Lange syndrome 4 | 614701 | 11, 10 |