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[Preprint]. 2023 Apr 19:2023.03.26.23287702. Originally published 2023 Mar 29. [Version 2] doi: 10.1101/2023.03.26.23287702

Figure 6: Schematic of the summary of findings.

Figure 6:

Resecting fast ripples on oscillations (fRonO) preceding spikes did not result in seizure freedom, thus the spike initiation zone (SIZ, blue) does not always strongly overlap with the epileptogenic zone (EZ, red). However, fRonO preceding spikes were found in greater proportions in the seizure onset zone (SOZ), so the SIZ does strongly overlap with the SOZ. Prior to spike initiation (right) a fRonO in the SIZ is generated with increased single unit firing rate relative to a smaller power FR in the EZ. Within 300 milliseconds of the FR occurring in the SIZ a fRonS or RonS in the SIZ is generated, suggesting the fRonO may facilitate the fRonS or RonS (HFO spike, right). Unit firing rate during an HFO spike in the SOZ, outside the SIZ, is relatively greater compared to the unit firing rate during the fRonS in the SIZ. The decreased excitability during the fRonS in the SIZ may be due to an inhibitory restraint mechanism that ordinarily prevents HFO spike initiation.