Table 2:
Association Between BMI Variability (Measured in SD and CV, per standard deviation) and Incident Heart Failure.
| Cohort | SD HR (95% CI), P | CV HR (95% CI), P | ||
|---|---|---|---|---|
| Model 1 | Model 2 | Model 1 | Model 2 | |
| Overall | 1.12 (1.1, 1.14), p<0.0001 | 1.05 (1.02, 1.07), p=0.0002 | 1.11 (1.08, 1.14), p<0.0001 | 1.06 (1.04, 1.09), p<0.0001 |
| Female | 1.15 (1.11, 1.19), p<0.0001 | 1.07 (1.03, 1.11), p=0.0009 | 1.14 (1.09, 1.19), p<0.0001 | 1.09 (1.04, 1.14), p<0.0001 |
| Male | 1.10 (1.08, 1.13), p<0.0001 | 1.03 (1, 1.06), p=0.0674 | 1.09 (1.05, 1.13), p<0.0001 | 1.04 (1.01, 1.08), p=0.0178 |
| Age < 60 years | 1.15 (1.11, 1.19), p<0.0001 | 1.07 (1.02, 1.12), p=0.0024 | 1.14 (1.09, 1.2), p<0.0001 | 1.09 (1.04, 1.15), p=0.0004 |
| Age ≥ 60 years | 1.11 (1.09, 1.14), p<0.0001 | 1.04 (1.01, 1.07), p=0.0076 | 1.1 (1.07, 1.14), p<0.0001 | 1.05 (1.02, 1.09), p=0.0006 |
| No Diabetes | 1.11 (1.09, 1.14), p<0.0001 | 1.04 (1.01, 1.07), p0.0023 | 1.11 (1.08, 1.14), p<0.0001 | 1.06 (1.03, 1.09), p<0.0001 |
| Diabetes | 1.17 (1.11, 1.23), p<0.0001 | 1.08 (1.02, 1.16), p=0.0119 | 1.15 (1.08, 1.22), p<0.0001 | 1.10 (1.03, 1.18), p=0.0053 |
| No Hypertension | 1.11 (1.09, 1.14), p<0.0001 | 1.05 (1.01, 1.08), p=0.0037 | 1.11 (1.08, 1.15), p<0.0001 | 1.06 (1.03, 1.1), p=0.0003 |
| Hypertension | 1.13 (1.1, 1.17), p<0.0001 | 1.05 (1.01, 1.09), p=0.0157 | 1.11 (1.07, 1.16), p<0.0001 | 1.06 (1.02, 1.11), p=0.003 |
| Normal Weight (Enrollment BMI≥18.5, <25 kg/m 2 ) | 1.07 (1.01, 1.13), p=0.03 | 1.09 (1.02, 1.18), p=0.016 | 1.08 (1.02, 1.15), p=0.0078 | 1.10 (1.03, 1.18), p=0.0068 |
| Overweight (Enrollment BMI≥25, <30 kg/m 2 ) | 1.07 (1.03, 1.11), p=0.0008 | 1.06 (1.01, 1.11), p=0.0118 | 1.08 (1.03, 1.13), p=0.0007 | 1.08 (1.02, 1.13), p=0.0029 |
| Obese (Enrollment BMI≥30 kg/m 2 ) | 1.13 (1.08, 1.17), p<0.0001 | 1.06 (1.02, 1.11), p=0.0039 | 1.09 (1.04, 1.15), p=0.0004 | 1.08 (1.03, 1.14), p=0.0011 |
Model 1 adjusted for age, sex, smoking history (current or previous smoking vs. never smoking), frequent alcohol consumption (≥ 3 times per week vs. less frequent), diabetes, hypertension, heart attack history, stroke history, atrial fibrillation history, high density lipoprotein cholesterol, low density lipoprotein, total cholesterol, triglycerides, estimated glomerular filtration rate.
Model 2 additionally adjusted for within-participant mean BMI across longitudinal measures. In stratified analyses, corresponding variable for the stratification was not included (e.g., sex was excluded in females or males only analysis).
Stratified analysis among underweight group was not performed due to the small sample size and number of events.