Table 1.
Putative causal genes/splicing site/proteins from TWAS/spTWAS/PWAS (PIP > 0.8).
| Type | Panel | Tissue | Chr | Symbol | Exon/Intron junction* | FUSION TWAS P-value | FOCUS LD block | FOCUS PIP† | |
|---|---|---|---|---|---|---|---|---|---|
| Artery | Brain | ||||||||
| TWAS | GTEx | Esophagus Mucosa | 4 | PLRG1 | - | 4.69e-13 | 155056126-157485097 | 1 | 1 |
| TWAS | GTEx | Pituitary | 4 | RP11-380D23.1 | - | 3.84e-06 | 111256567-113870102 | 0.999 | 0.999 |
| TWAS | GTEx | Cells Cultured Fibroblasts | 6 | FOXF2 | - | 1.74e-07 | 73924-1452362 | 0.995 | 0.995 |
| TWAS | GTEx | Brain Cortex | 9 | CDKN2A | - | 8.17e-07 | 20463534-22206559 | - | 0.87 |
| TWAS | GTEx | Artery Tibial | 11 | ANO1 | - | 4.50e-06 | 69516130-70926292 | 0.891 | - |
| spTW AS | GTEx | Nerve Tibial | 12 | MAPKAPK5-AS1 | 112279274-112279488 | 8.10e-15 | 110336719-113263518 | 0.965 | 0.966 |
| PWAS | ARIC | Plasma Protein | 4 | F11 | - | 1.82e-11 | 186909090-188472981 | 0.981 | - |
| PWAS | ARIC | Plasma Protein | 11 | MMP12 | - | 7.81e-10 | 101331121-103959636 | 0.865 | 0.865 |
| PWAS | ARIC | Plasma Protein | 17 | ENGASE | - | 1.55e-06 | 76263413-77298636 | 0.945 | - |
*:
All genomic locations are GRCh37.
†:
FOCUS PIP values are obtained by tissue prioritization using “Artery” or “Brain” tissue.