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X-ray co-crystal structure of 37 bound to WDR5 (PDB ID: 7UAS). (A) Compound 37 (white carbon-capped sticks) bound to WDR5 represented as semitransparent electrostatic potential surface with labeled S2, S4, and S7 binding regions. (B) Binding interactions of the (S)-1-cyclopropyl-1-(4-methylpyridine-2-yl)methyl P7 unit in the S7 subsite, pro(R)-H represented as a light orange ball. (C) Overlay of 20 (orange sticks) and 37 (white sticks).
