Table 1.
Demographic data of enrolled patients.
| IDH1-wt | IDH1-R132H | Value (P) | Difference (95% CI) | Total | |
|---|---|---|---|---|---|
| Age at diagnosis, mean (SD) | 55.58 ± 17.77 | 44.2 ± 12. 18 | Z = − 2.90 (0.004) | 16 (9–23) | 48.98 ± 14.37 |
| Sex, n (%) | Χ2 = 0.036 (0.851) | 0.025 (− 0.219 to 0.266) | |||
| Male | 11 (50) | 19 (47.5) | 30 (48.4) | ||
| Female | 11 (50) | 21 (52.5) | 32 (51.6) | ||
| Location, n (%) * | Χc2 = 15.07 (0.005) | ||||
| Frontal lobe | 7 (31.8) | 32 (80.0) | Χ2 = 14.12 (< 0.001) | 0.482 (0.226 to 0.663) | 39 (62.9) |
| Temporal lobe | 10 (45.5) | 5 (12.5) | Χ2 = 8.405(0.004) | 0.330 (0.100 to 0.541) | 15 (24.2) |
| Parietal lobe | 2 (9.1) | 2 (5.0) | – (0.61) | 0.041c (− 0.111 to 0.260) | 4 (6.5) |
| Occipital lobe | 1 (4.5) | 0 (0.0) | – (0.36) | 0.046c (− 0.072 to 0.249) | 1 (1.6) |
| Insular lobe | 2 (9.1) | 1 (9.1) | – (0.28) | 0.066c (− 0.078 to 0.284) | 3 (4.8) |
| Χc2 = 0.026 (0.987) | |||||
| Left cerebral hemisphere | 9 (40.9) | 17 (42.5) | Χ2 = 0.015 (0.903) | 0.016 (− 0.231 to 0.250) | 26 (41.9) |
| Right cerebral hemisphere | 12 (54.5) | 21 (52.5) | Χ2 = 0.024 (0.877) | 0.021 (− 0.226 to 0.259) | 33 (53.2) |
| Both right and left cerebral hemisphere | 1 (4.5) | 2 (5.0) | – (1.00) | 0.005c (− 0.20 to 0.14) | 3 (4.8) |
| Histopathology, n (%) | Χc2 = 14.12 (< 0.001) | ||||
| Oligodendroglioma | 2 (9.1) | 26 (65.0) | Χ2 = 17.914 (< 0.001) | 0.559 (0.316 to 0.704) | 28 (45.2) |
| Astrocytoma | 2 (9.1) | 7 (17.5) | Χc2 = 0.273 (0.601) | 0.084c (− 0.152 to 0.260) | 9 (14.5) |
| Glioblastoma | 18 (81.8) | 6 (15.0) | Χ2 = 26.710 (< 0.001) | 0.668 (0.421 to 0.803) | 24 (38.7) |
| Not classification | 0 (0.0) | 1 (2.5) | – (1.00) | 0.025c (− 0.162 to 0.147) | 1 (1.6) |
| WHO classification, n (%) | – (< 0.001) | ||||
| Grade 2 | 0 (0.0) | 11 (27.5) | – (0.005) | 0.275c (0.053 to 0.441) | 11 (17.7) |
| Grade 3 | 4 (18.2) | 23 (57.5) | Χ2 = 8.925 (0.003) | 0.393 (0.139 to 0.570) | 27 (43.5) |
| Grade 4 | 18 (81.8) | 6 (15.0) | Χ2 = 26.71 (< 0.001) | 0.668 (0.421 to 0.803) | 24 (38.7) |
| IDH1-wt | IDH1-R132H | Value (P) | Difference (95% CI) | Total | |
|---|---|---|---|---|---|
| Age at diagnosis, mean (SD) | 54.96 ± 11.26 | 44 ± 10.48 | Z = − 3.26 (0.001) | 14 (7–19) | 50.43 ± 12.13 |
| Sex, n (%) | Χ2 = 0.199 (0.766) | 0.066 (− 0.207 to 0.331) | |||
| Male | 16 (59.3) | 10 (52.6) | 26 (56.5) | ||
| Female | 11 (40.7) | 9 (47.4) | 20 (43.5) | ||
| Location, n (%) * | – (0.002) | ||||
| Frontal lobe | 8 (29.6) | 11 (57.9) | Χ2 = 3.675 (0.073) | 0.283 (− 0.004 to 0.517) | 19 (41.3) |
| Temporal lobe | 11 (40.7) | 1 (5.3) | Χc2 = 5.556 (0.018) | 0.355c (0.066 to 0.563) | 12 (26.1) |
| Parietal lobe | 3 (11.1) | 3 (15.8) | Χc2 = 0.000 (0,985) | 0.047c (− 0.178 to 0.307) | 6 (13.0) |
| Occipital lobe | 3 (11.1) | 0 (0.0) | – (0.257) | 0.111c (− 0.114 to 0.303) | 3 (6.5) |
| Insular lobe | 0 (0.0) | 4 (21.1) | – (0.024) | 0.211c (0.033 to 0.433) | 4 (8.7) |
| Others | 2 (7.4) | 0 (0.0) | – (0.504) | 0.074c (− 0.144 to 0.258) | 2 (4.3) |
| – (0.286) | |||||
| Left cerebral hemisphere | 11 (40.7) | 12 (63.2) | Χ2 = 2.242 (0.231) | 0.224 (− 0.064 to 0.464) | 23 (50.0) |
| Right cerebral hemisphere | 15 (55.6) | 7 (36.8) | Χ2 = 1.565 (0.245) | 0.187 (− 0.100 to 0.432) | 22 (47.8) |
| Both right and left cerebral hemisphere | 1 (3.7) | 0 (0.0) | – (1.000) | 0.037c (− 0.175 to 0.209) | 1 (2.2) |
| Histopathology, n (%) | – (< 0.001) | ||||
| Oligodendroglioma | 2 (7.4) | 9 (47.4) | Χc2 = 7.715 (0.005) | 0.400c (0.112 to 0.639) | 11 (23.9) |
| Astrocytoma | 2 (7.4) | 9 (47.4) | Χc2 = 7.715 (0.005) | 0.400c (0.112 to 0.639) | 11 (23.9) |
| Glioblastoma | 20 (74.1) | 0 (0.0) | – (< 0.001) | 0.741c (0.489 to 0.868) | 20 (43.5) |
| Not classification | 3 (11.1) | 1 (5.3) | Χc2 = 0.026 (0.872) | 0.059c (− 0.184 to 0.257) | 4 (8.7) |
| WHO classification, n (%) | Χc2 = 15.557 (0.001) | ||||
| Grade 2 | 4 (14.8) | 8 (42.1) | Χc2 = 3.009 (0.083) | 0.273c (− 0.016 to 0.532) | 12 (26.1) |
| Grade 3 | 2 (7.4) | 7 (36.8) | Χc2 = 4.412 (0.036) | 0.294c (0.026 to 0.547) | 9 (19.6) |
| Grade 4 | 21 (77.8) | 4 (21.0) | Χ2 = 14.463 (< 0.001) | 0.567 (0.277 to 0.738) | 25 (54.3) |
Significant values are in bold.