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. 2023 Mar 31;2023:1230182. doi: 10.1155/2023/1230182

Figure 5.

Figure 5

KDM2B expression is associated with GC progression and SAV1. TMA GC specimens were immunostained with a specific anti-KDM2B antibody. (a) Representative images of KDM2B expression in GC specimens and adjacent normal gastric tissue specimens. Markedly low KDM2B expression was observed in adjacent normal tissue (left panel), low KDM2B expression was observed in tumor tissue (middle panel), and high KDM2B expression was observed in tumor tissue (right panel). (b) KDM2B expression was significantly higher in tumors (TT) than that in adjacent normal tissue (TN). (c) KDM2B expression was negatively associated with the OS of patients with GC. (d) Representative images of high KDM2B expression and low SAV1 expression in TMA sections. (e) KDM2B and SAV1 protein expression in TMA sections from the cohort; the negative correlation between KDM2B and SAV1 expression was determined using Pearson's correlation coefficient analysis. N = 100. R = −0.535. P < 0.001. KDM2B, lysine-specific demethylase 2B; GC, gastric cancer; SAV1, Salvador homologue 1; OS, overall survival; TMA, tissue microarray.