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. 2023 Apr 7;9:11. doi: 10.1038/s41540-023-00274-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Distribution of Spearman correlations of pairwise comparisons between M1 and M1Smart simulations for knockout-strains and growth-phases. b Fraction of reactions significantly changed between simulations by models M1 and M1Smart (p-value < 0.1, Wilcoxon signed rank test). In the boxplots in a, the center lines represent the median; box limits represent upper and lower quartiles; whiskers extend to the first or last data point that is within 1.5× the interquartile range of the box limits in the lower and upper directions respectively. Dots are values outside of 1.5× interquartile range beyond either end of the box.