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. 2023 Apr 7;14:1958. doi: 10.1038/s41467-023-37537-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Contingency analysis showing the relationship between biallelic BRCA1/2 inactivation (BRCA1/2 mutations and BRCA1 methylation associated with LOH of the second allele) and response to platinum (Fisher’s exact test, two-sided). b BRCA1 gene expression determined by RT-PCR analysis in BRCA1 methylated PDX (n = 14) as compared to un-methylated PDX (n = 41). Data are presented as a Min/Max Whiskers plots with lines indicating the median. p = 0.0002 (Mann–Whitney test, two-tailed). c BRCA1 gene expression in BRCA1 methylated PDX according to the percentage of BRCA1 methylation. Each bar represents a single value d Waterfall plot representing platinum responses in PDX with biallelic inactivation of BRCA1/2: pathogenic BRCA1/2 mutations and BRCA1 methylation, associated with LOH. e Percentage of BRCA1/2 mutation and BRCA1 methylation in the 30 PDX with HRD based on shallow WGS. f PDX reponse to platinum according to the HRD status. p = 0.007, Fisher’s exact test (two-sided). g Correlation analysis between shallowHRD scores and CGH HRD score (Pearson correlation).