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. 2023 Apr 5;7(4):e858. doi: 10.1097/HS9.0000000000000858

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Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the European Hematology Association.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

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Figure 2. — High-grade CRS is characterized by high interleukin-6 levels, while severe infections are marked by baseline inflammation high procalcitonin levels. (A–B) Aggregated median procalcitonin values over time during the first 21 d after CAR-T infusion by CRS grade (A) and presence of severe infection (B). (C–D) Aggregated median CRP values by CRS grade (C) and presence of severe infection (D). (E–F) Aggregated median interleukin-6 values by CRS grade (E) and the presence of severe infection (F). Serum samples were prospectively collected in a laboratory panel that was performed at least daily during the first 2 wk and then as indicated. Significance values were determined with a mixed effects analysis considering both time and effect size. CAR-T = chimeric antigen receptor T-cell therapy; CRS = cytokine release syndrome.