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. 2023 Apr 5;7(4):e858. doi: 10.1097/HS9.0000000000000858

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Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the European Hematology Association.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

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Figure 6. — Severe infections are associated with distinct inflammatory signatures compared with CRS only controls. (A) Volcano plots showing the estimated mean difference between infection and CRS^only patients (x-axis), and corresponding −log10 (P values) (y-axis). Colors indicate proteins that passed the multiple testing adjusted P value threshold of P < 0.05. Each panel corresponds to one timepoint (days 0, 4, 14, 28). (B) Heatmap depicting normalized and centered NPX values (color scale) of the 16 proteins that differed between infection and CRS^only patients (significant main and/or interaction effect). Each row corresponds to a sample, and each column to a protein. Both rows and columns are sorted by hierarchical clustering, with dendrograms showing the clustering result. Time and severe infection status are indicated by the leftmost columns. (C) Differential expression per timepoint (from left to right) of the 16 proteins that differed between infection and CRS^only patients (significant main and/or interaction effect). The x-axis depicts the estimated mean difference between infection and CRS^only patients, and colors indicate the corresponding P values (not corrected for multiple testing). Each panel corresponds to one timepoint, with proteins sorted by NPX level changes (right: downregulated; left: upregulated in the Infection group). CRS = cytokine release syndrome; NPX = Normalized Protein eXpression.