(A) World map indicating multicenter–multinational study cohorts. (B) Kaplan-Meier curves for OS and PFS across development and external validation cohorts. OS was similar across all three sites, but PFS differed across the sites. BWH, Brigham and Women's Hospital, Boston, MA; OS, overall survival; PFS, progression-free survival; St Olav, St Olavs University Hospital, Trondheim, Norway; UCSF, University of California, San Francisco, CA.