Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Apr 8;14(4):255. doi: 10.1038/s41419-023-05786-0

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 1 — A CatB expression in various tissues. The data were obtained from the Genotype-Tissue Expression (GTEx) Project (https://gtexportal.org). Expression values are shown in TPM (transcripts per million), calculated from a gene model with isoforms collapsed to a single gene. B CatB maturation and lysosome-sorting pathway. C Methods to examine the lysosomal acid condition and CatB enzymatic activity. D’ Puncta signals (orange) of lysosomes with the acid environment and puncta signals (red) of CatB with enzymatic activity. D” LLOME increases the permeability of the lysosome membrane, resulting in a smaller number of acid lysosomes. LLOME-treated cells showed diffused CatB enzymatic activity. E Senescent cells showed CatB enzymatic activity in the nucleus but were not found in control cells.