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. Author manuscript; available in PMC: 2023 Apr 8.
Published in final edited form as: Trends Pharmacol Sci. 2019 Dec 17;41(1):55–65. doi: 10.1016/j.tips.2019.11.006

Figure 2.

Figure 2.

Graphic Overview of the CRISPR-based Ex Vivo and In Vivo Therapeutics. The CRISPR systems can be delivered ex vivo and in vivo by physical methods, viral vectors, biomaterials or their combinations. The dashed pink circle indicates procedures for the CRISPR-mediated genome editing ex vivo. The light green circle indicates in vivo therapeutic applications of the CRISPR system.