| Cochrane Risk of Bias Assessment |
| Author |
Title |
Random Sequence Generation |
Allocation Concealment |
Blinding of Outcome Assessment |
Incomplete Outcome Data |
Selective Reporting |
Citation |
| Agostinho |
Cucumis melo pectin as potential candidate to control herpes simplex virus infection |
Low |
Unclear |
Unclear |
Low |
Unclear |
[123] |
| Al-Salahi |
Molecular docking study and antiviral evaluation of2-thioxo-benzo[g]quinazolin-4(3H)-one derivatives |
Low |
Unclear |
Unclear |
Low |
Unclear |
[10] |
| Alvarez |
Cetylpyridinium chloride blocks herpes simplex virus replication in gingival fibroblasts |
Low |
Unclear |
Unclear |
Low |
Unclear |
[104] |
| Andrei |
The Anti-Human Immunodeficiency Virus Drug Tenofovir, a Reverse Transcriptase Inhibitor, Also Targets the Herpes Simplex Virus DNA Polymerase |
Low |
Unclear |
Unclear |
Low |
Unclear |
[49] |
| Andronova |
Study of Antiherpetic Efficiency of Phosphite of Acycloguanosine Able to Overcome the Barrier of Resistance to Acyclovir |
Unclear |
Unclear |
Unclear |
Unclear |
Unclear |
[13] |
| Arunkumar |
Study on antiviral activities, drug-likeness and molecular docking of bioactive compounds of Punica granatum L. to Herpes simplex virus - 2(HSV-2) |
Low |
Unclear |
Unclear |
Low |
Unclear |
[52] |
| Awad |
Synthesis and Evaluation of Some Uracil Nucleosides as Promising Anti-Herpes Simplex Virus 1 Agents |
Low |
Unclear |
Unclear |
Low |
Unclear |
[111] |
| Barboza |
In vitro effects of bufotenine against RNA and DNA viruses |
Low |
Unclear |
Unclear |
Low |
Unclear |
[126] |
| Bauer |
Antibody-based immunotherapy of aciclovir resistant ocular herpes simplex virus infections |
Unclear |
Unclear |
Unclear |
Unclear |
Unclear |
[27] |
| Ben-Amor |
Phytochemical Characterization of Olea europea Leaf Extracts and Assessment of Their Anti-Microbial and Anti-HSV-1 Activity |
Low |
Unclear |
Unclear |
Low |
Unclear |
[125] |
| Benassi-Zanqueta |
Evaluation of anti-HSV-1 activity and toxicity of hydroethanolic extract of Tanacetum parthenium (L.) Sch.Bip. (Asteraceae) |
Low |
Unclear |
Unclear |
Low |
Unclear |
[64] |
| Benzekri |
Anti HSV-2 activity of Peganum harmala (L.) and isolation of the active compound |
Low |
Unclear |
Unclear |
Low |
Unclear |
[32] |
| Bereczki |
Synthesis of Antiviral Perfluoroalkyl Derivatives of Teicoplanin and Vancomycin |
Low |
Unclear |
Unclear |
Low |
Unclear |
[89] |
| Bhutta |
Peptide Inhibitor of Complement C1, RLS-0071, Reduces Zosteriform Spread of Herpes Simplex Virus Type 1 Skin Infection and Promotes Survival in Infected Mice |
Unclear |
Low |
Unclear |
Low |
Unclear |
[134] |
| Bhutta |
Ginkgolic Acid Inhibits Herpes Simplex Virus Type 1 Skin Infection and Prevents Zosteriform Spread in Mice |
Unclear |
Low |
Unclear |
Low |
Unclear |
[120] |
| Bisignano |
Almond Skin Extracts Abrogate HSV-1 Replication by Blocking Virus Binding to the Cell |
Low |
Unclear |
Unclear |
Low |
Unclear |
[26] |
| Bonvicini |
Hemidesmus indicus (L.) R. Br. extract inhibits the early step of herpes simplex type 1 and type 2 replication |
Low |
Unclear |
Unclear |
Low |
Unclear |
[44] |
| Brenner |
The Molecular Tweezer CLR01 Inhibits Antibody-Resistant Cell-to-Cell Spread of Human Cytomegalovirus |
Low |
Low |
Low |
Low |
Unclear |
[136] |
| Brezáni |
Anti-Infectivity against Herpes Simplex Virus and Selected Microbes and Anti-Inflammatory Activities of Compounds Isolated from Eucalyptusglobulus Labill |
Low |
Unclear |
Unclear |
Low |
Unclear |
[138] |
| Cagno |
In vitro anti-herpes simplex virus-2 activity of Salvia desoleana Atzei &V. Picci essential oil |
Low |
Unclear |
Unclear |
Low |
Unclear |
[31] |
| Castillo |
Anti-herpetic Activity of Macrocystis pyrifera and Durvillaea antarctica Algae Extracts Against HSV-1 and HSV-2 |
Low |
Low |
High |
Low |
Unclear |
[110] |
| Chen |
Targeting Aryl Hydrocarbon Receptor Signaling Enhances Type I Interferon-Independent Resistance to Herpes Simplex Virus |
Low |
Unclear |
Unclear |
Low |
Unclear |
[112] |
| Crameri |
MxB is an interferon-induced restriction factor of human herpes viruses |
Low |
Low |
Low |
Low |
Unclear |
[53] |
| Criscuolo |
Synergy evaluation of anti-Herpes Simplex Virus type 1 and 2 compounds acting on different steps of virus life cycle |
Low |
Low |
Unclear |
HIgh |
Low |
[46] |
| Čulenová |
Multiple In vitro biological effects of phenolic compounds from Morus albaroot bark |
Low |
Low |
Unclear |
Unclear |
Unclear |
[85] |
| D'Aiuto |
R430: A potent inhibitor of DNA and RNA viruses |
Low |
Unclear |
Unclear |
Low |
Unclear |
[47] |
| Dai |
Antiviral Effect of Retro-2.1 against Herpes Simplex Virus Type 2 In Vitro |
Low |
Unclear |
Unclear |
Low |
Unclear |
[50] |
| Dai |
Antiviral Effects of ABMA against Herpes Simplex Virus Type 2 In Vitro and In Vivo |
Low |
Unclear |
Unclear |
Unclear |
Unclear |
[58] |
| Deback |
Antiviral effects of Cacicol(®), a heparan sulfate biomimetic for corneal regeneration therapy, for herpes simplex virus type-1 and varicella zoster virus infection |
Low |
Unclear |
Unclear |
Low |
Unclear |
[60] |
| Derby |
Griffithsin carrageenan fast dissolving inserts prevent SHIV HSV-2 and HPV infections in vivo |
Low |
Low |
Unclear |
Unclear |
Unclear |
[45] |
| Deschamps |
Discovery of Small-Molecule Inhibitors Targeting the E3 Ubiquitin Ligase Activity of the Herpes Simplex Virus 1 ICP0 Protein Using an In Vitro High-Throughput Screening Assay |
Unclear |
Low |
Low |
Unclear |
Unclear |
[82] |
| Ding |
T-type calcium channels blockers inhibit HSV-2 infection at the late stage of genome replication |
Unclear |
Low |
Unclear |
Low |
Unclear |
[102] |
| Ding |
Cellular Signaling Analysis shows antiviral, ribavirin-mediated ribosomal signaling modulation |
Low |
High |
Unclear |
Low |
Unclear |
[77] |
| Donalisio |
The traditional use of Vachellia nilotica for sexually transmitted diseases is substantiated by the antiviral activity of its bark extract against sexually transmitted viruses |
Low |
Unclear |
N/A |
Low |
Unclear |
[39] |
| Dong |
The Natural Compound Homoharringtonine Presents Broad Antiviral Activity In Vitro and In Vivo |
Unclear |
Low |
N/A |
Low |
Low |
[62] |
| Du |
The antiviral activity of arbidol hydrochloride against herpes simplex virus type II (HSV-2) in a mouse model of vaginitis |
Unclear |
Low |
Low |
Unclear |
Unclear |
[81] |
| El-Haddad |
Brincidofovir (CMX-001) for refractory and resistant CMV and HSV infections in immunocompromised cancer patients: A single-center experience |
Unclear |
Low |
Unclear |
N/A |
Low |
[1] |
| El-Shiekh |
Novel Antiviral and Antibacterial Activities of Hibiscus schizopetalus |
Low |
Unclear |
Unclear |
N/A |
Unclear |
[101] |
| Eletskaya |
Enzymatic synthesis of novel purine nucleosides bearing a chiral benzoxazine fragment |
Unclear |
High |
Low |
Unclear |
N/A |
[76] |
| Elias |
In Vitro Analysis of the Antioxidant and Antiviral Activity of Embelin against Herpes Simplex Virus-1 |
Low |
Unclear |
Unclear |
Low |
High |
[122] |
| Fujimoto |
Accumulation of a soluble form of human nectin-2 is required for exerting the resistance against herpes simplex virus type 2 infection in transfected cells |
Unclear |
Unclear |
Unclear |
Low |
N/A |
[17] |
| Fujimoto |
Evaluation of the antiviral potential of the soluble forms of glycoprotein D receptors on ocular herpes caused by HSV-1 and HSV-2 infections in a transgenic mouse model |
Low |
Low |
High |
N/A |
Unclear |
[73] |
| Fujimoto |
Comparison of the antiviral potential among soluble forms of herpes simplex virus type-2 glycoprotein D receptors, herpes virus entry mediator A, nectin-1 and nectin-2, in transgenic mice |
Low |
Low |
High |
Unclear |
N/A |
[28] |
| García-Serradilla |
Drug repurposing for new, efficient, broad-spectrum antivirals |
Low |
Unclear |
High |
Unclear |
N/A |
[65] |
| Ghaffari |
Inhibition of herpes simplex virus type 1 infection by Sambucus ebulus extract in vitro |
Low |
Unclear |
Low |
Unclear |
Unclear |
[132] |
| Ghosh |
Ficus religiosa L. bark extracts inhibit infection by herpes simplex virus type 2 in vitro |
Low |
Unclear |
Unclear |
Low |
Low |
[20] |
| González-García |
Antimicrobial Activity of Cyclic-Monomeric and Dimeric Derivatives of the Snail-Derived Peptide Cm-p5 against Viral and Multidrug-Resistant Bacterial Strains |
Unclear |
Low |
Unclear |
Unclear |
Low |
[135] |
| Greeley |
Acyclovir, cidofovir, and amenamevir have additive antiviral effects on herpes simplex virus TYPE 1 |
Unclear |
Low |
Low |
Unclear |
Unclear |
[95] |
| Hopkins |
In Vitro and In Vivo Activity, Tolerability, and Mechanism of Action of BX795 as an Antiviral against Herpes Simplex Virus 2 Genital Infection |
Unclear |
Low |
Unclear |
Unclear |
Low |
[100] |
| Hou |
Antiviral activity of PHA767491 against human herpes simplex virus in vitro and in vivo |
Low |
N/A |
Unclear |
Low |
Low |
[37] |
| Houston |
Potentiated virucidal activity of pomegranate rind extract (PRE) and punicalagin against Herpes simplex virus (HSV) when co-administered with zinc (II) ions, and antiviral activity of PRE against HSV and acyclovir-resistant HSV |
Unclear |
Low |
Low |
Unclear |
Unclear |
[30] |
| Huang |
Antiviral activity of mitoxantrone dihydrochloride against human herpes simplex virus mediated by suppression of the viral immediate early genes |
Low |
Low |
Unclear |
N/A |
Low |
[86] |
| Hutterer |
Inhibitors of dual-specificity tyrosine phosphorylation-regulated kinases (DYRK) exert a strong anti-herpes viral activity |
Unclear |
Low |
Low |
Unclear |
Low |
[38] |
| Ibáñez |
Pharmacological Induction of Heme Oxygenase-1 Impairs Nuclear Accumulation of Herpes Simplex Virus Capsids upon Infection |
N/A |
Low |
High |
Unclear |
Low |
[36] |
| Ireland |
Synthetic α-Hydroxytropolones Inhibit Replication of Wild-Type and Acyclovir-Resistant Herpes Simplex Viruses |
Unclear |
Low |
Unclear |
Low |
Unclear |
[9] |
| Ishimaru |
MG132 exerts anti-viral activity against HSV-1 by overcoming virus-mediated suppression of the ERK signaling pathway |
Low |
Low |
N/A |
Unclear |
Low |
[99] |
| Jaishankar |
An off-target effect of BX795 blocks herpes simplex virus type 1 infection of the eye |
Low |
N/A |
Unclear |
Low |
Unclear |
[56] |
| Jin |
Pentagalloyl glucose Blocks the Nuclear Transport and the Process of Nucleocapsid Egress to Inhibit HSV-1 Infection |
Low |
Unclear |
Unclear |
Low |
N/A |
[6] |
| Jones |
Modified cyclodextrins as broad-spectrum antivirals |
Low |
Low |
Unclear |
Unclear |
Unclear |
[93] |
| Kalke |
Herpes Simplex Virus Type 1 Clinical Isolates Respond to UL29-Targeted siRNA Swarm Treatment Independent of Their Acyclovir Sensitivity |
Low |
Low |
Unclear |
Low |
Unclear |
[98] |
| Kannan |
Anti-herpes virus activity of the carnivorous botanical, Sarraceniapurpurea |
N/A |
Low |
Low |
Unclear |
N/A |
[87] |
| Karpov |
[A Plasmid-Expressed CRISPR/Cas9 System Suppresses Replication of HSV Type I in a Vero Cell Culture] |
High |
Low |
Unclear |
Unclear |
Low |
[79] |
| Katsumata |
Antiviral efficacy of the helicase-primase inhibitor amenamevir in murine models of severe herpesvirus infection |
Low |
Unclear |
Unclear |
Unclear |
Low |
[43] |
| Kaushik |
Antiviral potential and mode of action of Indigofera heterantha against HSV-2 by targeting the early stages of infection |
Low |
Unclear |
Unclear |
Unclear |
Low |
[18] |
| Kim |
Quercus acuta Thunb. (Fagaceae) and Its Component, Isoquercitrin, InhibitHSV-1 Replication by Suppressing Virus-Induced ROS Production and NF-κB Activation |
Low |
Unclear |
Unclear |
Unclear |
Low |
[127] |
| Kim |
Mori ramulus and its Major Component Morusin Inhibit Herpes Simplex Virus Type 1 Replication and the Virus-Induced Reactive Oxygen Species |
Low |
Unclear |
Unclear |
Unclear |
Low |
[103] |
| Kongyingyoes |
3,19-isopropylideneandrographolide suppresses early gene expression of drug-resistant and wild type herpes simplex viruses |
Low |
Unclear |
Unclear |
Unclear |
Low |
[14] |
| Kumar |
Inhibition of herpes simplex virus-1 infection by MBZM-N-IBT: in silico and in vitro studies |
Low |
Unclear |
Unclear |
Unclear |
Low |
[133] |
| Labrunie |
UL23, UL30, and UL5 characterization of HSV1 clinical strains isolated from hematology department patients |
Low |
Unclear |
Unclear |
Unclear |
Low |
[84] |
| Le-Trilling |
Broad and potent antiviral activity of the NAE inhibitor MLN4924 |
Low |
Unclear |
Unclear |
Unclear |
Low |
[19] |
| Lebrun |
Varicella-Zoster Virus ORF9p Binding to Cellular Adaptor Protein Complex 1 Is Important for Viral Infectivity |
Low |
Unclear |
Low |
Unclear |
Low |
[139] |
| Lee |
Efficacy of brincidofovir as prophylaxis against HSV and VZV in hematopoietic cell transplant recipients |
High |
High |
High |
Unclear |
High |
[48] |
| Lei |
Preparation of a monoPEGylated derivative of cyanovirin-N and its virucidal effect on acyclovir-resistant strains of herpes simplex virus type 1 |
Low |
High |
High |
Unclear |
Low |
[2] |
| Li |
Amentoflavone Inhibits HSV-1 and ACV-Resistant Strain Infection by Suppressing Viral Early Infection |
Low |
Unclear |
Unclear |
Unclear |
Low |
[67] |
| Li |
Anti-herpes simplex virus type 1 activity of Houttuynoid A, a flavonoid from Houttuynia cordata Thunb |
Low |
Low |
Unclear |
Unclear |
Low |
[25] |
| Liu |
Antiviral activities of Janus-type nucleosides and their related oxime-intermediates |
Low |
Unclear |
Unclear |
Unclear |
Low |
[41] |
| Liu |
Harringtonine Inhibits Herpes Simplex Virus Type 1 Infection by Reducing Herpes Virus Entry Mediator Expression |
Low |
Unclear |
Unclear |
Unclear |
Low |
[116] |
| Lopes |
Sulfonated and Carboxymethylated β-Glucan Derivatives with Inhibitory Activity against Herpes and Dengue Viruses |
Low |
Unclear |
Unclear |
Unclear |
Low |
[128] |
| Luganini |
Effective deploying of a novel DHODH inhibitor against herpes simplex type 1 and type 2 replication |
Low |
Unclear |
Unclear |
Unclear |
Low |
[129] |
| Ma |
Herpes simplex virus type 1 (HSV-1) specific T-cell generation from HLA-A1- and HLA-A2-positive donors for adoptive immunotherapy |
Low |
Unclear |
Unclear |
Unclear |
Low |
[12] |
| Ma |
Assessment of a new arbidol derivative against herpes simplex virus II in human cervical epithelial cells and in BALB/c mice |
Low |
Low |
High |
Unclear |
Low |
[75] |
| Maizel |
Study of the Extremely-Tolerant Brevibacterium linens AE038-8 with Antiviral Activity Against Herpes Simplex Virus Type 1 |
Low |
Unclear |
Unclear |
Unclear |
Low |
[113] |
| Mandalari |
Simulated human digestion of N1-aryl-2-arylthioacetamidobenzimidazoles and their activity against Herpes-simplex virus 1 in vitro |
Low |
Unclear |
Unclear |
Unclear |
Low |
[72] |
| Marcocci |
The Amphibian Antimicrobial Peptide Temporin B Inhibits In Vitro Herpes Simplex Virus 1 Infection |
Low |
Unclear |
Unclear |
Unclear |
Low |
[54] |
| Marino-Merlo |
Anti-herpes simplex virus 1 and immunomodulatory activities of a poly-γ-glutamic acid from Bacillus horneckiae strain APA of shallow vent origin |
Low |
Unclear |
Unclear |
Unclear |
Low |
[29] |
| Mello |
Perillyl alcohol and perillic acid exert efficient action upon HSV-1maturation and release of infective virus |
Low |
Unclear |
Unclear |
Unclear |
Low |
[92] |
| Mishra |
Herbal Gel Formulation Developed for Anti-Human Immunodeficiency Virus (HIV)-1 Activity Also Inhibits In Vitro HSV-2 Infection |
Low |
Unclear |
Unclear |
Unclear |
Low |
[59] |
| Mohammed |
Synthesis and anti-HSV activity of tricyclic penciclovir and hydroxybutylguanine derivatives |
Low |
Unclear |
Unclear |
Unclear |
Low |
[69] |
| Monjo |
Photodynamic Inactivation of Herpes Simplex Viruses |
Low |
Unclear |
Unclear |
Unclear |
Low |
[55] |
| Moshaverinia |
Evaluation of the effect of hydro alcoholic extract of cinnamon on herpes simplex virus 1 |
Low |
Unclear |
Unclear |
Unclear |
Low |
[94] |
| Musarra-Pizzo |
The Antimicrobial and Antiviral Activity of Polyphenols from Almond (Prunus dulcis L.) Skin |
Low |
Unclear |
Unclear |
Unclear |
Low |
[68] |
| Novoa |
Antiviral Activity of Myticin C Peptide from Mussel: an Ancient Defense against Herpes viruses |
Low |
Unclear |
Unclear |
Unclear |
Low |
[8] |
| Paavilainen |
Topical treatment of herpes simplex virus infection with enzymatically created siRNA swarm |
Low |
Low |
High |
High |
Low |
[22] |
| Parsania |
Antiviral screening of four plant extracts against acyclovir resistant herpes simplex virus type-1 |
Low |
Unclear |
High |
Unclear |
Low |
[24] |
| PiresdeMello |
Aminomethylnaphthoquinones and HSV-1: in vitro and in silico evaluations of potential antivirals |
Low |
Unclear |
High |
Unclear |
Low |
[3] |
| Pradhan |
Herpes simplex virus virucidal activity of MST-312 and epigallocatechingallate |
Low |
Unclear |
High |
Unclear |
Low |
[63] |
| Praena |
Amidic derivatives of valproic acid, valpromide and valnoctamide, inhibitHSV-1 infection in oligodendrocytes |
Low |
Unclear |
High |
Unclear |
Low |
[78] |
| Pujol |
Polyhydroxylated sulfated steroids derived from 5α-cholestanes as antiviral agents against herpes simplex virus |
Low |
Unclear |
Unclear |
Unclear |
Low |
[16] |
| Quenelle |
Efficacy of pritelivir and acyclovir in the treatment of herpes simplex virus infections in a mouse model of herpes simplex encephalitis |
Low |
Low |
High |
Unclear |
Low |
[35] |
| Rechenchoski |
Mangiferin: A promising natural xanthone from Mangifera indica for the control of acyclovir - resistant herpes simplex virus 1 infection |
Low |
Low |
High |
Unclear |
Low |
[106] |
| Rittà |
Antiviral Activity of a Arisaema Tortuosum Leaf Extract and Some of its Constituents against Herpes Simplex Virus Type 2 |
Low |
Unclear |
High |
Unclear |
Low |
[91] |
| Ruzsics |
A Novel, Broad-Acting Peptide Inhibitor of Double-Stranded DNA Virus Gene Expression and Replication |
Low |
Low |
High |
Low |
Unclear |
[90] |
| Sacchelli |
Botryosphaeran and sulfonated derivatives as novel antiviral agents for herpes simplex and dengue fever |
Low |
Low |
High |
Low |
Unclear |
[74] |
| SadeghEhdaei |
Cellular miR-101-1 Reduces Efficiently the Replication of HSV-1 in HeLaCells |
Low |
Low |
High |
Unclear |
Unclear |
[114] |
| Sanchez |
Development and evaluation of a host-targeted antiviral that abrogatesherpes simplex virus replication through modulation of arginine-associated metabolic pathways |
Low |
Unclear |
High |
Unclear |
Unclear |
[11] |
| Sasaki |
In vitro and in vivo antiherpetic effects of(1R,2R)-1-(5'-methylful-3'-yl)propane-1,2,3-triol |
Low |
Unclear |
Unclear |
Low |
Unclear |
[15] |
| Schneider |
Early Steps in Herpes Simplex Virus Infection Blocked by a Proteasome Inhibitor |
Low |
Low |
Low |
Unclear |
Unclear |
[83] |
| Shabani |
Inhibition of herpes simplex virus type 1 replication by novel hsa-miR-7704 in vitro |
Low |
Unclear |
Unclear |
Unclear |
Unclear |
[71] |
| Shan |
Viral UL8 Is Involved in the Antiviral Activity of Oleanolic Acid Against HSV-1 Infection |
Low |
Unclear |
Unclear |
Low |
Unclear |
[130] |
| Shao |
Poly(dA:dT) Suppresses HSV-2 Infection of Human Cervical Epithelial Cells Through RIG-I Activation |
Unclear |
Unclear |
Unclear |
Unclear |
Unclear |
[124] |
| Sharifi-Rad |
Susceptibility of herpes simplex virus type 1 to monoterpenes thymol, carvacrol, p-cymene and essential oils of Sinapis arvensis L., Lallemantiaroyleana Benth. and Pulicaria vulgaris Gaertn |
Low |
Unclear |
Unclear |
Low |
Unclear |
[34] |
| Sharifi-Rad |
Antiviral activity of Veronica persica Poir. on herpes virus infection |
Unclear |
Unclear |
Unclear |
Unclear |
Unclear |
[51] |
| Shiraki |
Helicase-primase inhibitor amenamevir for herpesvirus infection: Towards practical application for treating herpes zoster |
Unclear |
Unclear |
Unclear |
Unclear |
Unclear |
[21] |
| Shiraki |
Amenamevir, a Helicase-Primase Inhibitor, for the Optimal Treatment of Herpes Zoster |
Low |
Unclear |
Low |
Low |
Unclear |
[121] |
| Spengler |
Antiviral, Antimicrobial and Antibiofilm Activity of Selenoesters and Selenoanhydrides |
Low |
Unclear |
Unclear |
Low |
Unclear |
[66] |
| Stegman |
Volatile Acid-Solvent Evaporation (VASE): Molecularly Homogeneous Distribution of Acyclovir in a Bioerodable Polymer Matrix for Long-Term Treatment of Herpes Simplex Virus-1 Infections |
Low |
Unclear |
Unclear |
Low |
Unclear |
[40] |
| Suryawanshi |
Bacterial Pigment Prodigiosin Demonstrates a Unique Anti herpesvirus Activity That Is Mediated through Inhibition of Pro survival Signal Transducers |
Low |
Unclear |
Unclear |
Low |
Unclear |
[109] |
| Tavakoli |
Inhibition of herpes simplex virus type 1 by copper oxide nanoparticles |
Low |
Unclear |
High |
Unclear |
Unclear |
[70] |
| Tintori |
Rhodanine derivatives as potent anti-HIV and anti-HSV microbicides |
Low |
Unclear |
Low |
Low |
Unclear |
[61] |
| Toscani |
Synthesis and Biological Evaluation of Amidinourea Derivatives against Herpes Simplex Viruses |
Low |
Low |
Low |
Low |
Unclear |
[118] |
| Toulabi |
The efficacy of olive leaf extract on healing herpes simplex virus labialis: A randomized double-blind study |
Low |
Unclear |
Unclear |
Low |
Low |
[119] |
| Tyo |
pH-responsive delivery of Griffithsin from electrospun fibers |
Low |
Unclear |
Unclear |
Low |
Unclear |
[80] |
| Uhlig |
Helicase primase inhibitors (HPIs) are efficacious for therapy of human herpes simplex virus (HSV) disease in an infection mouse model |
Low |
Low |
Low |
Low |
Unclear |
[137] |
| Urbancikova |
Efficacy of Pleuran (β-Glucan from Pleurotus ostreatus) in the Management of Herpes Simplex Virus Type 1 Infection |
Low |
Unclear |
Unclear |
Low |
Unclear |
[88] |
| Vanheule |
Basic chemokine-derived glycosaminoglycan binding peptides exert antiviral properties against dengue virus serotype 2, herpes simplex virus-1 and respiratory syncytial virus |
Low |
Unclear |
Unclear |
Low |
Unclear |
[7] |
| Viegas |
Antiviral activity of 1,4-disubstituted-1,2,3-triazoles against HSV-1 in vitro and effects of amino acid changes in drug-resistant α and β herpes viruses DNA polymerase |
Low |
High |
High |
Unclear |
Unclear |
[96] |
| VilasBoas |
Linear antimicrobial peptides with activity against herpes simplex virus 1 and Aichi virus |
Unclear |
High |
High |
Unclear |
Unclear |
[23] |
| Vilhelmova-Ilieva |
Antiviral Activity of Rosa damascena Mill. and Rosa alba L. Essential Oils against the Multiplication of Herpes Simplex Virus Type 1 Strains Sensitive and Resistant to Acyclovir |
Unclear |
High |
High |
Low |
Low |
[131] |
| Wang |
Guanidine modifications enhance the anti-herpes simplex virus activity of (E,E)-4,6-bis(styryl)-pyrimidine derivatives in vitro and in vivo |
Low |
Unclear |
Unclear |
Low |
Unclear |
[108] |
| Wang |
Anti-HSV-1 activity of Aspergilli peptide D, a cyclic pentapepetide isolated from fungus Aspergillus sp. SCSIO 41501 |
Low |
Unclear |
Unclear |
Low |
Unclear |
[107] |
| Whitley |
Clinical management of herpes simplex virus infections: past, present, and future |
N/A |
N/A |
N/A |
N/A |
N/A |
[57] |
| Wright |
Inhibition of Herpes Simplex Viruses, Types 1 and 2, by Ginsenoside 20(S)-Rg3 |
Low |
Unclear |
Unclear |
Low |
Low |
[105] |
| Ye |
Lupeol impairs herpes simplex virus type 1 replication by inhibiting the promoter activity of the viral immediate early gene α0 |
Low |
Unclear |
Unclear |
Low |
Unclear |
[115] |
| Zhang |
NSC23766 and Ehop016 Suppress Herpes Simplex Virus-1 Replication by Inhibiting Rac1 Activity |
Low |
Unclear |
Unclear |
Low |
Unclear |
[117] |
| Zhou |
Anti-HSV-1 effect of dihydromyricetin from Ampelopsis grossedentata via the TLR9-dependent anti-inflammatory pathway |
Low |
Unclear |
Unclear |
Low |
Unclear |
[97] |
| Zígolo |
Chemoenzymatic synthesis of new derivatives of glycyrrhetinic acid with antiviral activity. Molecular docking study |
Low |
Unclear |
Unclear |
Low |
Unclear |
[42] |
| Zinser |
A new promising candidate to overcome drug resistant herpes simplex virus infections |
Low |
Unclear |
High |
Low |
Unclear |
[33] |
