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. 2023 Apr 8;13:5790. doi: 10.1038/s41598-023-32545-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Photomicrographs showing minimizing of the myotoxic side effects of SV by using microsponges formulas in rats. (a) Control group showing the normal histological structure of the skeletal muscle in rat. The skeletal muscle was formed of several parallel elongated cylindrical muscle fibers (MF) with multiple flattened peripherally located nuclei (arrowhead) beneath the sarcolemma and acidophilic sarcoplasm. (b) Free SV group showing the myotoxic side effects of SV as; degenerated muscles fibers with deeply stained acidophilic sarcoplasm, pyknotic nucleus (arrowhead), hemorrhage (H) and leucocytic infiltration (LI). (c) FSV-6 group showing slight minimizing of the myotoxic side effects of SV by using microsponges formulation FSV-6. Note the deeply stained skeletal muscle fibers (MF) with multiple flattened peripherally located nuclei (arrowhead) beneath the sarcolemma. (d) FSV-1 group showing minimizing of the myotoxic side effects of SV by using microsponges formulation FSV-1.The skeletal muscle was formed of several parallel elongated cylindrical muscle fibers (MF) with acidophilic sarcoplasm and multiple flattened peripherally located nuclei (arrowhead) beneath the sarcolemma .Hx&E, scale bar = 50 μm. (B) Photomicrographs showing minimizing of the myotoxic side effects of SV by using microsponges formulas in rats. (a) Control group showing the normal skeletal muscle fibers (MF) with clear transvers striations (arrowhead). (b) Free SV group showing the myotoxic side effects of SV as; degenerated skeletal muscle fibers (DMF) with absence or ill clear transvers striations (arrowhead). (c) FSV-6 group showing skeletal muscle fibers (MF) with ill clear transvers striations (arrowhead). (d) FSV-1 group showing minimizing of the myotoxic side effects of SV. Note the skeletal muscle fibers (MF) with clear transvers striations (arrowhead). Silver impregnation technique, scale bar = 50 μm. (C) Negative images of the photomicrographs shown in (B).