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. 2023 Apr 8;13:119. doi: 10.1038/s41398-023-02414-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A Females: representative images showing c-Fos+ cells tagged with a green fluorescence protein (GFP) in the CeA. Scale bar = 100 μm. B Female vehicle vs. psilocin: histogram showing the number of c-Fos+ cells in each subregion of the CeA. CeC capsular CeA, CeM Medial CeA, CeL lateral CeA. Data points correspond to the mean of 2–4 hemispheres for each individual subject. C Males: representative images showing c-Fos+ cells tagged with a green fluorescence protein (GFP) in the CeA. Scale bar = 100 μm. D Male vehicle vs. psilocin: histogram showing the number of c-Fos+ cells in each subregion of the CeA. CeC capsular CeA, CeM medial CeA, CeL lateral CeA. Data points correspond to the mean of 2–4 hemispheres for each individual subject. E Female psilocin group: representative raw ΔF/F traces showing an individual at baseline and while on psilocin. Blue line = air-puff onset, Gray lines = individual traces, Green line = mean trace, Std standard deviation. F Females: Heatmaps comparing baseline to injection. Each row represents an individual subjects mean trace. G Female vehicle group: air-puff trace plots of changes in CeA fluorescence following exposure to a 500 ms air-puff at 85 psi. Data points represent group averages within 500 ms binned window +/− S.E.M. H Female psilocin group: air-puff trace plots of changes in CeA fluorescence following exposure to a 500 ms air-puff at 85 psi. Data points represent group averages within 500 ms binned window +/− S.E.M. I Male psilocin group: representative raw ΔF/F traces showing an individual at baseline and while on psilocin. Blue line = air-puff onset, Gray lines = individual traces, Green line = mean trace, Std standard deviation. J Males: Heatmaps comparing baseline to injection. Each row represents an individual subjects mean trace. K Male vehicle group: air-puff trace plots of changes in CeA fluorescence following exposure to a 500 ms air-puff at 85 psi. Data points represent group averages within 500 ms binned window +/− S.E.M. L Male psilocin group: air-puff trace plots of changes in CeA fluorescence following exposure to a 500 ms air-puff at 85 psi. Data points represent group averages within 500 ms binned window +/− S.E.M. In each trace bin plot panel, a significant increase in ΔF/F was determined whenever the lower bound of the 99% CI was >0. These points of statistical significance are shown as colored lines above each ΔF/F curve with colors corresponding to the respective binned traces with a * above the lines. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.