Fig. 5. Changes in CeA reactivity in response to an auditory stimulus following psilocin administration in female subjects.
A Female vehicle group: representative mean ΔF/F traces showing an individual at initial auditory compared to final auditory. Blue line = air-puff onset, Gray lines = individual traces, Green line = mean trace, Std standard deviation. B Female vehicle group: peak point of binned mean ΔF/F traces compared between initial and final auditory recordings. Data points represent each individual subject’s peak ΔF/F value +/− S.E.M. C Female vehicle group: air-puff trace plots of changes in CeA fluorescence following exposure to a 500 ms air-puff at 85 psi. Data points represent group averages within 500 ms binned window +/− S.E.M. D Female vehicle group: Heatmaps comparing initial to final auditory. Each row represents an individual subjects mean trace. E Female psilocin group: representative mean ΔF/F traces showing an individual at initial auditory compared to final auditory. Blue line = air-puff onset, Gray lines = individual traces, Green line = mean trace, Std standard deviation. F Female psilocin group: peak point of binned mean ΔF/F traces compared between initial and final auditory recordings. Data points represent individual subject’s peak ΔF/F value +/− S.E.M. G Female psilocin group: air-puff trace plots of changes in CeA fluorescence following exposure to a 500 ms air-puff at 85 psi. Data points represent group averages within 500 ms binned window +/− S.E.M. H Female psilocin group: Heatmaps comparing initial to final auditory. Each row represents an individual subjects mean trace. In each trace bin plot panel, a significant increase in ΔF/F was determined whenever the lower bound of the 99% CI was >0. These points of statistical significance are shown as colored lines above each ΔF/F curve with colors corresponding to the respective binned traces with a * above the lines. **p < 0.01.