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. 2023 Apr 8;14(4):257. doi: 10.1038/s41419-023-05755-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A The number of eccDNA types and involved genes from normal and NSCLC tissues. B The distribution of eccDNAs in the 23 pairs of chromosomes. C The eccDNA frequency per Mb in each chromosome. D There was a significant correlation between the number of coding genes in a given chromosome and the number of eccDNAs derived from the chromosome (P = 0.047). E, F The distribution of eccDNAs in different classes of genomic regions. G The length distribution of eccDNAs ranged from 0.01 kb to 1000 kb. H A Venn diagram showing the consistent eccDNAs detected in the NSCLC and matched normal lung tissue samples. I The distribution of consistent eccDNAs in different classes of genomic regions. J A Venn diagram showing the consistent genes detected in the NSCLC and matched normal lung tissue samples. K–M The cellular components, molecular functions, and biological processes associated with the consistent eccDNAs. N KEGG pathway analysis of the consistent eccDNAs between NSCLC and matched normal lung tissue. O, P Volcano plot and histogram showing that there were no differentially expressed eccDNAs between NSCLC and matched normal lung tissues. EccDNA extrachromosomal circular DNA, NSCLC non-small cell lung cancer, Mb megabase.