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. 2023 Apr 8;14(4):257. doi: 10.1038/s41419-023-05755-7

Fig. 2. Genome-wide detection and analysis of eccDNA distribution by high-throughput sequencing in NSCLC cells and normal cells.

Fig. 2

A The number of eccDNA types and involved genes from normal and NSCLC cells. B The distribution of eccDNAs in the 23 pairs of chromosomes. C The eccDNA frequency per Mb in each chromosome. D There was no significant correlation between the number of coding genes and eccDNAs in each chromosome (P = 0.0636). E, F The distribution of eccDNAs in different classes of genomic regions. G, H The length distribution of eccDNA ranged from 0.01 kb to 1000 kb. I A Venn diagram showing the eccDNAs detected in NSCLC and normal lung cells. J–L The cellular components, molecular functions, and biological processes associated with the eccDNAs. M KEGG pathway analysis of the eccDNAs between NSCLC and normal lung cells. EccDNA extrachromosomal circular DNA, NSCLC non-small cell lung cancer, Mb megabase.