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. 2023 Apr 8;14(4):257. doi: 10.1038/s41419-023-05755-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A PCA of NSCLC cells and normal cells according to differences in eccDNA-related genes. B, C Cluster and scatter plots showing the differentially expressed eccDNA-related genes between NSCLC cells and normal cells. D PPI analysis of the major differentially expressed eccDNA-derived genes from STRING (https://string-db.org/). E–G The cellular components, molecular functions, and biological processes associated with the differentiated eccDNA-related genes. H KEGG pathway analysis of the eccDNA-related genes between NSCLC and normal lung cells. EccDNA extrachromosomal circular DNA, NSCLC non-small cell lung cancer.