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. 2023 Apr 8;13:5770. doi: 10.1038/s41598-023-33009-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Differentially expressed genes (DEGs) of high- and low-risk groups and regulatory network construction of hub genes. (A,B) Volcano plots and heatmaps of DEGs according to high- and low-risk scores. (C) The DEGs’ protein–protein interaction network was developed using STRING. (D) Hub genes were identified using the CytoHubba algorithm. (E) Transcription factor regulatory networks of 8 hub genes. (F) miRNA regulatory networks of the hub genes.