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. Author manuscript; available in PMC: 2023 Apr 9.
Published in final edited form as: J Am Chem Soc. 2022 Mar 15;144(12):5214–5225. doi: 10.1021/jacs.2c00224

Figure 1.

Figure 1.

Biocatalysis in convergent synthesis. (a) Comparison of target product yields in hypothetical linear versus convergent synthetic routes. (b) Representative retrosynthesis of alkaloid natural product core 1 using chemical methods compared to enzymatic convergence with a cytochrome P450 enzyme shows transformative power of biocatalysis in convergent synthesis.