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. 2015 Jun 3;2015(6):CD000179. doi: 10.1002/14651858.CD000179.pub3

Comparison 1. Pyridoxine (B6) versus control.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Pre‐eclampsia 2   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
1.1 Antenatal oral pyridoxine versus control 2 1197 Risk Ratio (M‐H, Fixed, 95% CI) 1.71 [0.85, 3.45]
1.2 Antenatal pyridoxine lozenges versus control 1 944 Risk Ratio (M‐H, Fixed, 95% CI) 1.43 [0.64, 3.22]
2 Eclampsia 3   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
2.1 Antenatal oral pyridoxine versus control 3 1242 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
2.2 Antenatal pyridoxine lozenges versus control 1 944 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
3 Dental decay (increase in decayed, missing or filled teeth) 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
3.1 Antenatal oral pyridoxine versus control 1 371 Risk Ratio (M‐H, Fixed, 95% CI) 0.84 [0.71, 0.98]
3.2 Antenatal pyridoxine lozenges versus control 1 342 Risk Ratio (M‐H, Fixed, 95% CI) 0.68 [0.56, 0.83]
4 Breastmilk production (g/kg/day) 1   Mean Difference (IV, Fixed, 95% CI) Subtotals only
4.1 Oral pyridoxine loading dose versus control in labour 1 24 Mean Difference (IV, Fixed, 95% CI) ‐2.30 [‐16.46, 11.86]
4.2 Intramuscular pyridoxine loading dose versus control in labour 1 24 Mean Difference (IV, Fixed, 95% CI) ‐6.20 [‐21.99, 9.59]
5 Mean birthweight (kg) 1   Mean Difference (IV, Fixed, 95% CI) Subtotals only
5.1 Antenatal oral pyridoxine versus control 1 33 Mean Difference (IV, Fixed, 95% CI) ‐0.23 [‐0.42, ‐0.04]
6 Low Apgar score at 1 minute 2   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
6.1 Antenatal oral pyridoxine versus control 1 45 Risk Ratio (M‐H, Fixed, 95% CI) 1.85 [0.11, 31.00]
6.2 Oral pyridoxine loading dose versus control in labour 1 24 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
6.3 Intramuscular pyridoxine loading dose versus control in labour 1 24 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
7 Low Apgar score at 5 minutes 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
7.1 Oral pyridoxine loading dose versus control in labour 1 24 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
7.2 Intramuscular pyridoxine loading dose versus control in labour 1 24 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]