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. 2023 Mar 18;44(2):315–322. doi: 10.24272/j.issn.2095-8137.2022.399

Table 1. Summary of adult primate hippocampal neurogenesis studies using sc-RNA-seq or sn-RNA-seq.

Method Species Tissue Number of cells Cell population Platform Neurogenesis Notes Studies
Sn-RNA-seq Cynomolgus monkey Eight young and aged CA1, CA3, and DG 8 000 nuclei 12 clusters 10x Genomics Yes Neural transiently amplifying progenitor cell and microglia were most affected by aging Zhang et al., 2021
Sn-RNA-seq Human 38 human post-mortem hippocampi 32 103 nuclei 14 clusters SPLiT-Seq Yes Novel candidate gene STMN1 in human immature neurons Zhou et al., 2022
Sn-RNA-seq Sc-ATAC-seq Human,macaque 13 macaque and four human donor hippocampi 132 524 nuclei 13 clusters 10x Genomics Yes for both ETNPPL as a primate-specific NSC marker. STMN1 and STMN2 as immature neuronal markers in primates Wang et al., 2022
Sc-RNA-seq Macaque Eight adult macaque hippocampi 207 785 cells 34 clusters 10x Genomics Yes HMGB2 as a novel intermediate progenitor cell marker Hao et al., 2022
Sn-RNA-seq Human, macaque, pig Human post-mortem DG, CA2–CA4, CA1, Sub, and EC 219 058 nuclei 69 Clusters 10x Genomics Yes for macaques,No for humans METTL7B-defined subregion-specific excitatory neurons and astrocytes in primates Franjic et al., 2022