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. 2023 Mar 27;14:1107511. doi: 10.3389/fendo.2023.1107511

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Copyright © 2023 Wang, Greenbaum, Qiu, Gong, Wang, Lin, Liu, He, Meng, Zhang, Shen, Vemulapalli, Sanchez, Schiller, Xiao and Deng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Single-cell clustering analysis. (A) Single-cell clustering results after CCA integration analysis. (B) The upper panel shows cell cluster information of microenvironment cells before integration analysis using the same clustering layout in panel (A) The middle panel shows cell cluster information of OB sorting dataset before integration analysis using the same clustering layout. The lower panel markers the source of each cell. (C) Cell developmental trajectory inference of OBC-1 and OBC-2. The upper-right trajectory plot indicates the direction of pseudotime. (D) Cell lineage relationships in panel (C). (E) Expression levels (log-normalized) of indicated genes with respect to their pseudotime coordinates. The x-axis indicates the pseudotime, while the y-axis represents the log-normalized gene expression levels. Black lines depict the LOESS regression fit of the normalized expression values. (F) Continuum of up regulated-genes in cell fate 1 around branch point 2 in panel (D) Cell fate 1 is correlated to the left branch after branch point 2 in panel (D) Marked names of ossification-related genes. (G) GO analysis results of up regulated-genes in cell fate 1.