Table 1.

Detailed information on sample origin, number of cells, and sequencing methodology of each dataset.

Dataset	Sample origin	Number of cells/samples	Sequencing methodology
Microenvironment dataset	Femur head-derived bone tissue	8952 cells	scRNA-seq
OB sorting dataset	Femur head-derived bone tissue	8728 cells	scRNA-seq
CCA integration dataset	Femur head-derived bone tissue	17680 cells	scRNA-seq
Blood monocytes dataset	Peripheral blood monocytes	339 cells	scRNA-seq
Male monocytes dataset	Peripheral blood monocytes	944 samples	RNA-seq
Female osteoporosis dataset	Peripheral blood monocytes	80 samples	mRNA transcriptome array