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. 2023 Mar 27;14:1022090. doi: 10.3389/fphar.2023.1022090

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Copyright © 2023 Shao, Bao, Davies Forsman, Paues, Werngren, Niward, Schön, Bruchfeld, Alffenaar and Hu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Classification and Regression Tree analysis for the thresholds to differentiate the 2-month, 6-month sputum conversion and successful treatment outcome in the validation cohort. Classification and Regression Tree analysis was applied to identify the thresholds predictive of 2-month (A), 6-month (B) sputum conversion and successful treatment outcome (C). AUC_0-24h: area under drug concentration-time curve over the last 24-h dosing interval; MIC: minimum inhibitory concentration.