TABLE 4.
Association between the thresholds and sputum culture conversion among the participants in the validation cohort.
| Robust Poisson regression model | Cox proportional hazards regression model | |||||
|---|---|---|---|---|---|---|
| Sputum culture conversion (%) | RR (95%CI) | aRR (95%CI) a | Median time (month) to culture conversion (IQR) | HR (95%CI) | aHR (95%CI) a | |
| 2-month threshold | ||||||
| AUC0-24h/MIC≤175.5 (n = 51) | 5.9 | 1 | 1 | 14 (5,19) | 1 | 1 |
| AUC0-24h/MIC>175.5 (n = 108) | 100.0 | 17 (5.7–51) | 16.4 (5.3–50.4) | 1 (1,2) | 27.3 (8.7–86.3) | 29.4 (9.1–95.1) |
| 6-month threshold | ||||||
| AUC0-24h/MIC≤118.2 (n = 26) | 3.8 | 1 | 1 | 18 (14,24) | 1 | 1 |
| AUC0-24h/MIC>118.2 (n = 133) | 91.7 | 23.8 (3.5–163.1) | 20.1 (2.9–139.4) | 2 (1,2) | 47.9 (6.6–344.9) | 42.5 (5.9–308.9) |
| 24-month threshold | ||||||
| AUC0-24h/MIC≤74.6 (n = 10) | 10 | 1 | 1 | 24 (24,24) | 1 | 1 |
| AUC0-24h/MIC>74.6 (n = 149) | 99.3 | 9.9 (1.5–63.8) | 9.7 (1.5–64.8) | 2 (1,3) | 36.4 (5–265.8) | 31.3 (4.2–232.8) |
RR: relative risk; CI: confidence interval; IQR: interquartile range; HR: hazard ratio.
a
Adjusted according to age, sex, place of residency, weight, adherence and baseline time to liquid culture positivity. Non-adherence was defined as discontinued for more than 3 days.