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. 2023 Mar 27;14:1139281. doi: 10.3389/fendo.2023.1139281

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Copyright © 2023 Shao, Wang, Wen, Xie, Huang, Guan, Hao, Duan, Chen and Chen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of aging on the interactions between CD51+ SLCs and CD51++ macrophages. (A, B) Testosterone production by separately cultured (CD51++ MF or CD51+ SLC) or co-cultured (SLC/MF) cells in the presence of differentiation inducing medium. (C, D) Percentage of testosterone production by separately cultured cells (YMF, YSLC, OMF or OSLC) or co-cultured cells within same ages (YSLC/YMF or OSLC/OMF) or across different ages (YSLC/OMF or OSLC/YMF) in the presence of differentiation inducing medium. The data are expressed as mean ± SEM of 3-7 individual experiments. (ND) not detected. *Significantly different from time-matched CD51+ SLC controls at P < 0.05 respectively.