Table 1.
Patient characteristics and bone health parameters before and after switch.
| TDF arm | p-value1 | TAF arm | p-value2 | |||
|---|---|---|---|---|---|---|
| Baseline | 24-weeks | Baseline | TAF arm 24-weeks | |||
| Cohort | N=12 | N=12 | N=12 | N=12 | ||
| Age, median years (IQR) | 46 (40-53) | 44 (36-48) | ||||
| Male, n(%) | 10 (83%) | 9 (75%) | ||||
| Smoker, n(%) | 2 (14%) | 3 (25%) | ||||
| Weight (Kg) | 76.9 (71-85) | 77 (67-88) | 0.594 | 75.3 (70-84) | 77 (73 – 89) | 0.031 |
| Body Mass Index (BMI) | 25.3 (24-27) | 26.1 (22-27) | 0.594 | 24.6 (23-29) | 27.1 (23.9-29.9) | 0.026 |
| Regimen at baseline | ||||||
| Rilpivirine | 4 (34%) | 6 (50%) | ||||
| Elvitegravir/cobicistat | 4 (34%) | 5 (41%) | ||||
| Efavirenz | 1 (9%) | 1 (9%) | ||||
| Boosted Darunavir | 2 (14%) | 0 | ||||
| Raltegravir | 1 (9%) | 0 | ||||
| Bone Parameters | ||||||
| BMSi | 82.35 (76-85) | 82 (73.5-83) | 0.812 | 81.6 (79-83) | 86 (80-88) | 0.041 |
| Lumbar spine BMD (g/cm2) | 0.985 (0.804-1.042) | 0.991(0.811-1.042) | 0.552 | 0.981(0.851-1.036) | 0.979 (0.863-1.041) | 0.504 |
| Femoral neck BMD (g/cm2) | 0.739 (0.673-0.892) | 0.794 (0.689-0.893) | 0.109 | 0.792(0.723-0.830 | 0.791 (0.668-0.824) | 0.929 |
| T-score spine | -0.9 (-2.2 - -0.4) | -0.9 (-2.1 - -0.3) | 0.978 | -1 (-2 - -0.4) | -1 (-1.9 – 0) | 0.367 |
| T-score femoral neck | -1.3 (-1.7 - -0.2) | -1(-1.6 – 0.1) | 0.067 | -0.75(-1.35 - -0.6) | -0.8(-1.9 - -0.5) | 0.836 |
| Bone Metabolism Markers | ||||||
| P1NP (ng/ml) | 54.9 (46-100) | 46 (37-69) | 0.031 | 59.3 (46-73) | 47 (39-59) | 0.032 |
| CTX (ng/ml) | 0.351 (0.317-0.427) | 0.441 (0.314-0.712) | 0.916 | 0.362 (0.264-0.556) | 0.355 (0.230-0.459) | 0.028 |
| Bone Alkaline Phosphatase (µg/ml) | 17 (14-21) | 15.8 (14.6-17.9) | 0.109 | 14.5 (12.4-17.4) | 10.5 (8.9-14.2) | 0.202 |
| iPTH(pg/ml) | 33 (25-47) | 34 (24-48) | 0.735 | 35(26-43) | 38(26-44) | 0.342 |
| 25OH Vitamin D (ng/ml) | 26.3 (26-31) | 20 (17-24) | 0.009 | 25 (11-34) | 16 (6-28) | 0.003 |
| HIV specific parameters | ||||||
| CD4+ T-cell/ml median (IQR) | 584 (574-892) | 631 (602-738) | 0.327 | 609 (390-751) | 740 (412-1093) | 0.012 |
| CD4/CD8 ratio median (IQR) | 1.06 (0.986-1.224) | 0.928 (0.798-1.235) | 0.674 | 0.851 (0.595-1.230) | 0.761 (0.593-1.104) | 0.139 |
| Viral load median (IQR) | 19 (9.5-19) | 19 (0-19) | 0.373 | 19 (19-19) | 19 (0-19) | 0.973 |
Results are shown as median values (IQR), unless indicated otherwise. 1 corresponds to the p-value when comparing TDF arm 24-week to baseline. 2 corresponds to the p-value when comparing TAF arm 24 week to baseline. Bold font represents significant differences after 24 weeks.