TABLE 2.

Experimentally determined structures of 7SK RNP domains.

PDB ID	RNA domain(s)	Protein domain(s)	Year released	Method	Resolution	Comments	References
RNA
2KX8	SL4	n/a	2010	NMR	n/a	Bound to arginine	Durney and D’Souza (2010)
5IEM	SL1 distal	n/a	2016	NMR	n/a		Bourbigot et al. (2016)
5LYS	SL1 distal	n/a	2017	X-ray	2.32 Å	Gold derivative	Martinez-Zapien et al. (2017)
5LYU	SL1 distal	n/a	2017	X-ray	2.20 Å		Martinez-Zapien et al. (2017)
5LYV	SL1 distal	n/a	2017	X-ray	2.35 Å	Osmium derivative	Martinez-Zapien et al. (2017)
6MCI	SL1 distal	n/a	2018	NMR	n/a		Pham et al. (2018)
6MCF	SL1 distal	Tat ARM	2018	NMR	n/a	Peptide sequence: GISYGRKKRRQRRRAHQ	Pham et al. (2018)
7T1N	SL1 distal	HEXIM1 ARM	2022	NMR	n/a	Peptide sequence: GISYGRQLGKKKHRRRAHQ	Pham et al. (2022)
7T1O	SL1 distal	Tat subtype G ARM	2022	NMR	n/a	Peptide sequence: GISYGRKKRRHRRRAHQ	Pham et al. (2022)
7T1P	SL1 distal	Tat Finland ARM	2022	NMR	n/a	Peptide sequence: GISYGRKKRKHRRRAHQ	Pham et al. (2022)
Core RNP
5UNA	n/a	MePCE MTase	2017	X-ray	2.55 Å	Initial deposition 3G07 in 2009	n/a
4WKR	3′ UUU-OH	Larp7 La module	2015	X-ray	3.20 Å	construct residues 1-208	Uchikawa et al. (2015)
5KNW	n/a	Larp7 xRRM2	2016	NMR	n/a		Eichhorn et al. (2016)
6D12	SL4 upper stem	Larp7 xRRM2	2018	X-ray	2.20 Å		Eichhorn et al. (2018)
6DCB	SL1 proximal	MePCE MTase	2019	X-ray	2.00 Å	Substrate RNA	Yang et al. (2019)
6DCC	SL1 proximal	MePCE MTase	2019	X-ray	2.10 Å	Capped product RNA	Yang et al. (2019)
7SLP	Minimal 7SK SL1+SL4	Larp7, MePCE MTase	2022	CryoEM	4.10 Å	“Linear” model	Yang et al. (2022)
7SLQ	Minimal 7SK SL1+SL4	Larp7, MePCE MTase	2022	CryoEM	3.70 Å	“Circular” model	Yang et al. (2022)
P-TEFb assembly
2GD7	n/a	HEXIM1	2007	NMR	n/a		Dames et al. (2007)
3S9G	n/a	HEXIM1 coiled-coil	2011	X-ray	2.10 Å	Δstammer	Bigalke et al. (2011)