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. 2023 Mar 27;14:1149185. doi: 10.3389/fphar.2023.1149185

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Copyright © 2023 Li, Su, Chen, Cao, Liu and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gavage with Lactobacillus reuteri improved intestinal tight junctions (n = 8–9/group). (A) H&E staining of the colon tissues. (B) AB-PAS staining of the colon tissues. (C) Number of goblet cells, intestinal wall thickness, villus height and intestinal mucus thickness of the colon tissues. (D) mRNA expression levels of ZO-1, Occludin, Claudin-1, Claudin-2, and KLF4 in the colon tissues. Data are shown as the mean ± SEM. *p < 0.05, **p < 0.01 (Statistical comparisons between the two groups were performed using the two independent samples t-test. Comparisons between multiple groups were performed using One-way ANOVA and Tukey test.).