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. 2023 Mar 27;14:1113455. doi: 10.3389/fimmu.2023.1113455

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Copyright © 2023 Sun, Liu, Wu, Ning, Hu, Chen, Wu and Yin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Evaluate the expression level of BSG in HCC cell line, and then verify the intervention efficiency. (A) Compared with HL-7702(normal liver cell), BSG is generally highly expressed in tumor cells and has the highest expression in SMMC7721. (B) Differential protein expression of BSG between hepatocytes and hepatoma cells. (C) Verification of intervention efficiency through western blot. (D) The expression of BSG protein was significantly reduced in SMMC-7721 cells after the intervention of BSG expression. **P value<0.01; ***P value<0.001; ns, Not Significant.