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. 2023 Mar 27;14:1146612. doi: 10.3389/fimmu.2023.1146612

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Copyright © 2023 Liu, Zhou, Tu, Yao, Li and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pyroptosis of macrophages induced by purification of NETs in vitro. Bone marrow macrophages(BMDMs)were co-incubated with NETs in concentration gradients (0, 3, 6, 9 ug/ml, 24 h) or time gradients (0, 6, 12, 24 h, 6 ug/ml). (A–D) Immunoblot analysis of pyroptosis-related proteins (Cl-caspase-1, Cl-GSDMD, ASC) expression. (E, F) Level of inflammatory cytokine IL-1β in cell supernatant was detected by ELISA. Data were represented as mean ± S.D. (n = 3). “ns” represents no significant difference, *P < 0.05, **P < 0.01, ***P<0.001, ****P < 0.0001.