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. 2023 Mar 27;14:1136408. doi: 10.3389/fneur.2023.1136408

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Copyright © 2023 Churchill, Roudaia, Chen, Gilboa, Sekuler, Ji, Gao, Lin, Jegatheesan, Masellis, Goubran, Rabin, Lam, Cheng, Fowler, Heyn, Black, MacIntosh, Graham and Schweizer.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of ongoing symptom count on functional connectivity for individuals with COVID-19. (A) significant connections are depicted by lines connecting regions of interest (ROIs), with warm colors indicating increased connectivity with greater symptom count, and cool colors denoting decreased connectivity; line colors denote the strength of effect in terms of bootstrap ratio (BSR) and node sizes denote the number of significant connections. (B) heatmap showing the percentage of significant connections that are between each pair of lobes; a ‘*’ denotes significantly elevated connections for the lobe pair. (C) scatterplot showing mean connectivity values within regions of significant increase, plotted against symptom count, for individuals in the COVID-19 and control groups; solid lines denote the lines of best fit and shaded areas denote the 95%CIs of the mean.