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. 2023 Mar 17;11(3):282–292. doi: 10.1002/ueg2.12375

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© 2023 The Authors. United European Gastroenterology Journal published by Wiley Periodicals LLC on behalf of United European Gastroenterology.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Positive staining pattern of all targets in the high‐grade dysplasia (HGD) or T1 colorectal cancer (T1CRC) component. For each target, an illustrative case was selected with positive expression (i.e. staining score >1) in the HGD‐T1CRC component. The region enclosed by the rectangle with dashed line consists of HGD or T1CRC. An overview image (left) and enlargement of the HGD‐T1CRC region (right) are provided for each target. (a) CEA expression and (b) c‐MET expression. (c) EpCAM expression. (d) FRα expression. (e) αvβ6 expression. CEA, carcinoembryonic antigen; c‐MET, c‐mesenchymal‐epithelial transition factor; EpCAM, epithelial cell adhesion molecule; FRα, folate receptor.