TABLE 2.
The mean immunoreactive score (IRS) for the component of normal tissue, low‐grade dysplasia (LGD), high‐grade dysplasia (HGD), and T1 colorectal cancer (T1CRC) (minimum 0, maximum 12).
| Target | Normal mean IRS (n = 57) | LGD mean IRS (n = 58) | HGD‐T1CRC mean IRS (n = 60) | p‐value normal versus HGD‐T1CRC | p‐value LGD versus HGD‐T1CRC |
|---|---|---|---|---|---|
| CEA | 0.08 | 1.83 a | 4.78 | <0.001 | <0.001 |
| c‐MET | 0.02 | 2.64 | 3.58 | <0.001 | 0.003 |
| EpCAM | 8.79 | 10.95 | 11.75 | <0.001 | 0.011 |
| FRα | 0.04 | 0.70 | 1.23 | 0.001 | 0.051 |
| αvβ6 | 0.42 a | 1.01 | 0.76 | 0.075 | 0.930 |
Abbreviations: CEA, carcinoembryonic antigen; c‐MET, c‐mesenchymal‐epithelial transition factor; EpCAM, epithelial cell adhesion molecule; FRα, folate receptor alpha; IRS, immunoreactive score.
a
Data of one case was missing due to a broken slide on which the IRS of that component could not be assessed properly.