Table 2.

Domains and their definitions.

Domain	Domain definition
Burden of disease	Relates to number of people affected or severity of disease, including measures of health service need/demand/use that are not explicitly translated into health system costs (e.g., risk of admission to hospital). Does not include the economic burden of a disease, which is captured in other domains.
Equity/Fairness/Ethics/Equality	Relates to any issues linked to equity, fairness, ethics or equality, pertaining to the disease/risk factor itself (e.g., whether they disproportionately impact vulnerable groups), or the intervention (e.g., whether it specifically targets and reduces inequity). For example, these issues could relate to characteristics such as gender, sexual orientation, ethnicity, education or wealth, or to reducing inequalities.
Cost-effectiveness/value for money	Relates to explicit consideration or calculation of the balance between costs and benefit of an intervention/programme, e.g., cost effectiveness ratios (ICERs), cost per quality-adjusted life year (QALY), or cost per identified benefit. This includes criteria reported in studies simply as “value for money” or “cost-effectiveness” with no further detail.
Budget impact of the intervention/programme	Relates to the budget impact of investment or disinvestment in the programme for the body funding it.
Cost of disease from a health system perspective	Relates to the health system cost of providing care for people with a disease, i.e., economic burden of disease for the health system.
Cost of disease from a patient perspective	Relates to the cost to patients of obtaining care for a disease.
Cost of disease from a societal perspective	Relates to the cost of a disease to wider society, e.g., through Absenteeism (from work or school) Loss of productivity Need for informal care Impact on wider industries and the economy.
Health and wellbeing impacts of intervention/programme	Relates to positive and negative health and wellbeing outcomes of the intervention/programme. For example, effectiveness/efficacy of intervention/programme, including comparative (dis)advantage versus other options, side effects or harms associated with the intervention/programme. Also includes changes in, e.g., knowledge and behaviour, as these have the potential to lead to changes in health and wellbeing outcomes.
Social considerations	Relates to the social aspects of the disease or the intervention/programme. For example, fear/risk perception/stigma of the disease itself, societal acceptability of a programme/intervention, impact of a programme/intervention on wider societal outcomes including community capacity.
Organisational/provider/industry considerations	Relates to the acceptability and impact of the intervention/programme to the public health organisation carrying out the prioritisation, providers such as healthcare professionals or wider healthcare industry bodies. Includes whether the intervention is included in clinical guidelines & practises, or if there is evidence of variation in practise, and whether a disease is difficult to manage. It also includes alignment with organisational priorities/strategy.
Legal & regulatory framework	Relates to any legislative or regulatory requirements or issues relating to the intervention/programme which affect provision/implementation. For example, this includes national level decisions about inclusion of an intervention in provision (e.g., inclusion of a vaccine in the national vaccine programme) which need to be complied with at regional or local level.
Political considerations	Relates to any political considerations, such as alignment with government policy.
International support/donor acceptance	Relates to alignment with international policy or donor strategy/priorities, including acceptability of prioritisation of the disease or of the intervention/programme.
Feasibility of implementation	Relates to the feasibility of implementing an intervention/programme and any factors affecting this. For example, whether an effective prevention or treatment is available for a disease, what proportion of the affected population a programme/intervention could target, the ability to provide quality care, or any capacity constraints or technical issues with providing an intervention/programme. (Does not include any feasibility considerations falling under other domains, e.g., budget impact or legal & regulatory framework).
Current provision of services	Relates to existing provision of services in the community. For example, whether an intervention/programme or alternative measures are being provided in the community, or what access is like to the services.
Evidence considerations	Relating to issues around the evidence-base, such as availability/strength/quality of evidence about the impact of an intervention/programme.