Table 2.

Protein-protein interactions prediction from Interolog- and Domain-based approaches using BLAST parameters: 50% sequence identity, 1e-05 e-value, and 50% sequence coverage.

Prediction method	Standard database	NC_003310			MT903344			ON563414
		Interactions	Host	Pathogen	Interactions	Host	Pathogen	Interactions	Host	Pathogen
Interolog	BioGRID	21	20	4	20	19	3	21	20	4
	DIP	31	23	11	23	20	9	26	23	10
	HPIDB	1,144	940	48	1,122	932	42	1,129	936	44
	IntAct	372	269	23	366	269	22	366	269	22
	MINT	73	64	13	72	63	12	72	63	12
	VirHostNET	817	720	43	803	715	38	807	719	39
	Interolog (Total)	1,197	981	52	1,174	976	46	1,182	981	48
Domain	3did	8,644	3,165	76	5,994	3,165	68	6,196	3,264	74
	DOMINE	25,669	3,044	73	21,217	2,967	65	22,533	3,021	71
	IDDI	89,813	7,264	98	79,453	7,236	89	85,333	7,349	95
	Domain (Total)	97,696	7,441	106	85,452	7,416	96	92,154	7,522	102
Interolog & Domain (combined)		98,827	7,998	121	86,555	7,968	110	93,265	8,076	117