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. 2023 Mar 5;101:skad073. doi: 10.1093/jas/skad073

Table 3.

Change from baseline serum metabolite concentrations of obese dogs during weight loss

ΔWeek 0 to 6 ΔWeek 0 to 12 ΔWeek 0 to 18 ΔWeek 0 to 24 P-value
Item FT1 OR1 FT OR FT OR FT OR SEM2 diet week
--- mg/dL ---
Creatinine 0.07 -0.03 0.15 0.03 0.25 0.07 0.15 0.03 0.07 0.0814 0.0237
BUN3 −3.67 −5.00 −3.08 −5.58 0.67 −4.08 −2.33 −5.92 1.91 0.0016 0.0642
Calcium 0.15 0.24 −0.45 −0.29 −0.67 −0.39 −0.73 −0.56 0.09 0.1239 <0.0001
Phosphorus −0.53 −0.78 −0.35 −0.41 −0.21 −0.81 −0.41 −0.83 0.27 0.0349 0.7919
Glucose −4.17 −3.42 −5.33 −7.33 −7.83 −8.58 −7.17 −7.83 3.10 0.8618 0.0890
Total bilirubin −0.02 0.03 0.00 0.03 0.02 0.08 0.06 0.08 0.01 0.0061 <0.0001
Total cholesterol −36.75 −19.92 −43.17 −34.75 −63.08 −57.17 −65.17 −77.58 14.36 0.3993 <0.0001
Triglycerides −17.42 −39.25 −26.33 −40.08 −21.08 −38.92 −25.58 −45.92 10.44 0.0198 0.7855
Bicarbonate 0.83 −0.75 0.00 −0.92 0.08 −0.50 −0.25 −1.00 0.79 0.3690 0.3491
--- g/dL ---
Total protein 0.26 0.04 −0.12 −0.12 −0.35 −0.51 −0.18 −0.47 0.20 0.9853 <0.0001
Albumin −0.13 −2.56 −0.14 −2.55 −0.37 −2.66 −0.35 −2.70 1.81 0.0018 0.0086
Globulin 0.14 0.05 0.03 −0.12 −0.23 −0.40 −0.08 −0.33 0.08 0.0622 <0.0001
--- mmol/L ---
Sodium 1.33 0.92 −0.17 0.08 −0.75 0.67 −0.42 0.75 0.58 0.4388 0.0152
Potassium 0.09 −0.05 0.10 −0.07 0.08 −0.14 0.04 −0.14 0.08 0.0684 0.4338
Chloride 1.83 1.50 1.00 1.08 1.25 2.08 1.33 2.92 0.60 0.4494 0.0244
U/L
Total ALP3 −8.50 −16.17 −14.25 −31.00 −18.92 −41.33 −20.83 −48.58 8.90 0.0237 0.0065
CALP3 0.00 −8.25 −3.67 −17.58 −6.58 −27.17 −7.00 −32.08 7.23 0.0147 0.0284
ALT3 −4.25 24.08 −9.17 −0.42 0.25 −6.42 −10.33 −10.25 10.97 0.9357 0.2050
GGT3 1.42 0.42 −0.08 0.42 1.00 0.83 1.00 1.00 0.75 0.7078 0.0014
CPK3 0.42 −7.75 −21.92 −37.67 −9.75 −39.92 −10.00 −39.33 9.85 0.0136 0.0233
A/G3 ratio −0.09 −0.03 −0.07 0.04 −0.02 0.15 −0.09 0.08 0.04 0.0002 0.2099
Na/K ratio −0.58 0.58 −1.00 0.58 −0.75 1.25 −0.58 1.17 0.69 0.0619 0.5991
Anion gap −0.33 0.25 −0.25 −0.17 −1.08 −1.08 −0.67 −1.42 0.39 0.9589 0.0017

1FT, Fit & Trim (Champion Petfoods LP); OR, Orijen Original (Champion Petfoods LP).

2SEM, pooled standard error of the means.

3BUN, blood urea nitrogen; total ALP, total alkaline phosphatase; CALP, corticosteroid isoenzyme of ALP; ALT, alanine aminotransferase; GGT, gamma-glutamyltransferase; CPK, creatine phosphokinase; A/G, albumin/globulin.