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. 2023 Apr 7;9(2):e002971. doi: 10.1136/rmdopen-2022-002971

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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(A) Disease duration for SSc patients, stratified for sex. (A) Shows the disease duration for patients included in the Leiden CCISS cohort, stratified for sex, per cohort-entry year. (B) Disease duration for SSc patients, stratified for autoantibody status. (B) shows the disease duration for patients included in the Leiden CCISS cohort, stratified for autoantibodies (ATA and ACA positive), per cohort-entry year. ACA, anticentromere autoantibody; ATA, antitopoisomerase autoantibody; CCISS, Combined Care in Systemic Sclerosis; RP, Raynaud’s phenomenon; SSc, systemic sclerosis.