Table 1.
Baseline characteristics and treatments of patients with GCA
(N=65) | |
Age, mean (SD) | 70.8 (9.2) |
Female sex | 44 (67.7) |
Biopsy-proven disease | 40 (61.5) |
Imaging-proven disease* | 21 (32.3) |
New-onset disease at TCZ initiation† | 27 (41.5) |
Initial TCZ treatment | |
4 mg/kg intravenously monthly | 2 (3.1) |
8 mg/kg intravenously monthly | 13 (22.0) |
162 mg subcutaneously every 2 weeks | 6 (9.2) |
162 mg subcutaneously weekly | 44 (67.7) |
Use of other immunosuppressants for GCA | |
Concurrent with TCZ | 2 (3.1)‡ |
Previous to TCZ | 8 (12.3)§ |
On prednisone at TCZ initiation | 65 (100) |
Daily prednisone dose (mg) at TCZ initiation, mean (SD) | 33.9 (21.5) |
Patients receiving >1 TCZ course | 13 (20.0) |
Duration of first TCZ course (years), mean (SD) | 1.9 (1.1) |
Total duration of TCZ treatment (years), mean (SD) | 2.2 (1.6)¶ |
Values represent number and (%) unless otherwise specified.
*Ultrasound, CT angiography, MR angiography or positron emission tomography showing arterial lesions suggestive of vasculitis.
†TCZ started within 12 weeks of GCA diagnosis without preceding disease flare.
‡Methotrexate in both cases.
§Including methotrexate, cyclophosphamide, ustekinumab, abatacept, tofacitinib and secukinumab.
¶Aggregated time on TCZ for patients who received more than one TCZ course.
GCA, giant cell arteritis; TCZ, tocilizumab.