Table 1.

Overview on DC subsets and surface receptors for targeting approaches

	cDC1 (type I conventional DCs)	cDC2 (type II conventional DCs)	pDCs (plasmacytoid DCs)	MoDCs (monocyte‐derived DCs)	LCs (Langerhans cells)
Function	Cross‐presentation and priming of CD8+ T cells against extracellular antigens	Strong CD4+ T‐cell priming but also CD8+ T‐cell responses; most numerous subset in blood and tissues	Major producers of type I interferons upon virus infection	Develop from monocytes in vivo and in vitro during inflammation	antigen presentation to CD4+ and CD8+ T cells; role in tolerance induction
Surface molecules for targeting approaches	Clec9A/DNGR‐1 DEC‐205 XCR1	Clec10A/MGL Clec4a2/DCIR‐1 Clec7A/dectin‐1 DEC‐205 MR/CD206	Clec4C/BDCA‐2 DCIR‐1	DC‐SIGN/CD209 MR/CD206 DEC‐205 DCIR‐1	Langerin/CD207 DEC‐205