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. 2022 Jul 12;42(6):540–547. doi: 10.1111/neup.12848

Table 1.

Review of clinical features in pathologically proven cases of diffuse astrocytoma (formerly GC) presenting with parkinsonism (n/a, not available)

Characteristic Tagliati (2000) 11 Slee (2006) 12 Oliviera (2018) 1 Jang (2013) 10 Asada (2007) 14
Clinical diagnosis Idiopathic Parkinson's disease Sporadic Creutzfeldt‐Jakob disease Dementia with Lewy Bodies Juvenile parkinsonism Parkinsonism
Levodopa response Partial n/a No No No
Pyramidal signs Present Absent Absent Absent Present
Cognitive impairment Present Present Present Present Absent
Sphincter disturbance Urinary urgency Urinary incontinence Absent Absent n/a
Falls < 3y from onset Yes No Yes No Yes
MR imaging findings T2 hyperintensity in left temporal lobe and bilateral thalami Symmetrical T2 hyperintensity of the thalami, lentiform nuclei, heads of the caudate nuclei. Diffuse T2 hyperintensity with focal ring‐enhancing nodules Left parietal T2 high signal

Extensive bilateral diffuse T2 high‐intensity lesions in fronto‐parietal white matter

T2 hypointensity in left putamen

Gliomatosis pathology distribution Pons, midbrain, basal ganglia, amygdala, cortex Right temporal lobe (biopsy) Identified on brain biopsy Identified on brain biopsy Cerebral white matter (biopsy)